CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine-specific demethylase 6A 
Protein Synonyms/Alias
 Histone demethylase UTX; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 
Gene Name
 Kdm6a 
Gene Synonyms/Alias
 Utx 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
397SGLAARIKYLQAQLCubiquitination[1]
799VGPGTCDKVNNIHPTacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). 
Sequence Annotation
 REPEAT 95 128 TPR 1.
 REPEAT 132 165 TPR 2.
 REPEAT 169 203 TPR 3.
 REPEAT 207 240 TPR 4.
 REPEAT 245 285 TPR 5.
 REPEAT 286 319 TPR 6.
 REPEAT 321 353 TPR 7.
 REPEAT 355 387 TPR 8.
 DOMAIN 1095 1258 JmjC.
 METAL 1146 1146 Iron (By similarity).
 METAL 1148 1148 Iron (By similarity).
 METAL 1226 1226 Iron (By similarity).
 METAL 1331 1331 Zinc (By similarity).
 METAL 1334 1334 Zinc (By similarity).
 METAL 1358 1358 Zinc (By similarity).
 METAL 1361 1361 Zinc (By similarity).
 MOD_RES 769 769 Phosphoserine (By similarity).
 MOD_RES 829 829 Phosphoserine.
 MOD_RES 1061 1061 Phosphoserine.  
Keyword
 Alternative splicing; Chromatin regulator; Complete proteome; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1401 AA 
Protein Sequence
MKSCGVSLAT AAAAAAAAAF GDEEKKMAAG KASGESEEAS PSLTAEEREA LGGLDSRLFG 60
FVRFHEDGAR MKALLGKAVR CYESLILKAE GKVESDFFCQ LGHFNLLLED YPKALSAYQR 120
YYSLQSDYWK NAAFLYGLGL VYFHYNAFQW AIKAFQEVLY VDPSFCRAKE IHLRLGLMFK 180
VNTDYESSLK HFQLALVDCN PCTLSNAEIQ FHIAHLYETQ RKYHSAKEAY EQLLQTENLS 240
AQVKATILQQ LGWMHHTVDL LGDKATKESY AIQYLQKSLE ADPNSGQSWY FLGRCYSSIG 300
KVQDAFISYR QSIDKSEASA DTWCSIGVLY QQQNQPMDAL QAYICAVQLD HGHAAAWMDL 360
GTLYESCNQP QDAIKCYLNA TRSKNCSNTS GLAARIKYLQ AQLCNLPQGS LQNKTKLLPS 420
IEEAWSLPIP AELTSRQGAM NTAQQNTSDN WSGGNAPPPV EQQTHSWCLT PQKLQHLEQL 480
RANRNNLNPA QKLMLEQLES QFVLMQQHQM RQTGVAQVRP TGILNGPTVD SSLPTNSVSG 540
QQPQLPLTRM PSVSQPGVHT ACPRQTLANG PFSAGHVPCS TSRTLGSTDT VLIGNNHVTG 600
SGSNGNVPYL QRNAPTLPHN RTNLTSSTEE PWKNQLSNST QGLHKGPSSH LAGPNGERPL 660
SSTGPSQHLQ AAGSGIQNQN GHPTLPSNSV TQGAALNHLS SHTATSGGQQ GITLTKESKP 720
SGNTLTVPET SRQTGETPNS TASVEGLPNH VHQVMADAVC SPSHGDSKSP GLLSSDNPQL 780
SALLMGKANN NVGPGTCDKV NNIHPTVHTK TDNSVASSPS SAISTATPSP KSTEQTTTNS 840
VTSLNSPHSG LHTINGEGME ESQSPIKTDL LLVSHRPSPQ IIPSMSVSIY PSSAEVLKAC 900
RNLGKNGLSN SSILLDKCPP PRPPSSPYPP LPKDKLNPPT PSIYLENKRD AFFPPLHQFC 960
TNPNNPVTVI RGLAGALKLD LGLFSTKTLV EANNEHMVEV RTQLLQPADE NWDPTGTKKI 1020
WHCESNRSHT TIAKYAQYQA SSFQESLREE NEKRSHHKDH SDSESTSSDN SGKRRKGPFK 1080
TIKFGTNIDL SDDKKWKLQL HELTKLPAFV RVVSAGNLLS HVGHTILGMN TVQLYMKVPG 1140
SRTPGHQENN NFCSVNINIG PGDCEWFVVP EGYWGVLNDF CEKNNLNFLM GSWWPNLEDL 1200
YEANVPVYRF IQRPGDLVWI NAGTVHWVQA IGWCNNIAWN VGPLTACQYK LAVERYEWNK 1260
LQNVKSIVPM VHLSWNMARN IKVSDPKLFE MIKYCLLRTL KQCQTLREAL IAAGKEIIWH 1320
GRTKEEPAHY CSICEVEVFD LLFVTNESNS RKTYIVHCQD CARKTSGNLE NFVVLEQYKM 1380
EDLMQVYDQF TLAPPLPSAS S 1401 
Gene Ontology
 GO:0035097; C:histone methyltransferase complex; ISO:MGI.
 GO:0071558; F:histone demethylase activity (H3-K27 specific); IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0048333; P:mesodermal cell differentiation; IMP:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0048570; P:notochord morphogenesis; IMP:MGI.
 GO:0003016; P:respiratory system process; IMP:MGI.
 GO:0032525; P:somite rostral/caudal axis specification; IMP:MGI. 
Interpro
 IPR003347; JmjC_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF02373; JmjC
 PF00515; TPR_1
 PF13181; TPR_8 
SMART
 SM00558; JmjC
 SM00028; TPR 
PROSITE
 PS51184; JMJC
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS