UniProt Accession

 D6RFE4_HUMAN; D6RFE4 

Genbank Protein ID

 AC019131 

Genbank Nucleotide ID

  

Protein Name

 Alcohol dehydrogenase class-3 

Protein Synonyms/Alias

  

Gene Name

 ADH5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
84	GEGVTKLKAGDTVIP	ubiquitination	[1, 2]
101	IPQCGECKFCLNPKT	ubiquitination	[2]
107	CKFCLNPKTNLCQKI	ubiquitination	[2, 3]
113	PKTNLCQKIR*****	ubiquitination	[2, 4]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 115 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004022; F:alcohol dehydrogenase (NAD) activity; IEA:Compara.
 GO:0051903; F:S-(hydroxymethyl)glutathione dehydrogenase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006068; P:ethanol catabolic process; IEA:Compara.
 GO:0046294; P:formaldehyde catabolic process; IEA:Compara.
 GO:0018119; P:peptidyl-cysteine S-nitrosylation; IEA:Compara.
 GO:0045777; P:positive regulation of blood pressure; IEA:Compara.
 GO:0003016; P:respiratory system process; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0051409; P:response to nitrosative stress; IEA:Compara.
 GO:0001523; P:retinoid metabolic process; IEA:Compara. 

Interpro

 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like. 

Pfam

 PF08240; ADH_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS