UniProt Accession

 LKHA4_MOUSE; P24527; Q3UY71; Q8VDR8 

Genbank Protein ID

 M63848; AK134931; BC021417 

Genbank Nucleotide ID

 AAB59675.1; BAE22342.1; AAH21417.1 

Protein Name

 Leukotriene A-4 hydrolase 

Protein Synonyms/Alias

 LTA-4 hydrolase; Leukotriene A(4) hydrolase 

Gene Name

 Lta4h 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
58	RSLTLDTKDLTIEKV	ubiquitination	[1]
73	VINGQEVKYTLGESQ	ubiquitination	[1]
230	SEKEQVEKSANEFSE	ubiquitination	[1]
337	CGRLFGEKFRHFHAL	acetylation	[2]
414	FLKAYVKKFSYQSVT	acetylation	[2]
434	SFLYSHFKDKVDLLN	ubiquitination	[1]
519	PLPLGHIKRMQEVYN	acetylation	[2]
519	PLPLGHIKRMQEVYN	ubiquitination	[1]
547	LRLCIQSKWEEAIPL	acetylation	[2]
573	KFTRPLFKDLAAFDK	acetylation	[2]
580	KDLAAFDKSHDQAVH	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. 

Sequence Annotation

 REGION 135 137 Substrate binding (By similarity).
 REGION 267 272 Substrate binding (By similarity).
 REGION 564 566 Substrate binding (By similarity).
 ACT_SITE 297 297 Proton acceptor (By similarity).
 ACT_SITE 384 384 Proton donor (By similarity).
 METAL 296 296 Zinc; catalytic.
 METAL 300 300 Zinc; catalytic.
 METAL 319 319 Zinc; catalytic.
 MOD_RES 73 73 N6-acetyllysine (By similarity).
 MOD_RES 337 337 N6-acetyllysine (By similarity).
 MOD_RES 414 414 N6-acetyllysine (By similarity).
 MOD_RES 416 416 Phosphoserine (By similarity).
 MOD_RES 573 573 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Leukotriene biosynthesis; Metal-binding; Metalloprotease; Phosphoprotein; Protease; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 611 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.
 GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.
 GO:0004463; F:leukotriene-A4 hydrolase activity; ISS:UniProtKB.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB.
 GO:0043171; P:peptide catabolic process; ISS:UniProtKB.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR016024; ARM-type_fold.
 IPR012777; Leukotriene_A4_hydrolase.
 IPR001930; Peptidase_M1.
 IPR015211; Peptidase_M1_C.
 IPR014782; Peptidase_M1_N. 

Pfam

 PF09127; Leuk-A4-hydro_C
 PF01433; Peptidase_M1 

SMART

  

PROSITE

 PS00142; ZINC_PROTEASE 

PRINTS

 PR00756; ALADIPTASE.