UniProt Accession

 STN1_HUMAN; Q9H668; D3DR99; Q5TCZ0 

Genbank Protein ID

 AK026212; AL133355; CH471066; CH471066; BC017400 

Genbank Nucleotide ID

 BAB15396.1; CAB81623.1; EAW49619.1; EAW49620.1; AAH17400.1 

Protein Name

 CST complex subunit STN1 

Protein Synonyms/Alias

 Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog 

Gene Name

 OBFC1 

Gene Synonyms/Alias

 STN1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	LYNGHPIKQVDVLGT	ubiquitination	[1]
91	INCICWKKLNTESVS	ubiquitination	[1, 2]
114	LSLTSQLKKLQETIE	ubiquitination	[1]
115	SLTSQLKKLQETIEQ	ubiquitination	[1]
123	LQETIEQKTKIEIGD	ubiquitination	[1, 2]
125	ETIEQKTKIEIGDTI	ubiquitination	[1, 3]
176	ELPTIYRKVYDQPFH	ubiquitination	[1, 2]
189	FHSSALEKEEALSNP	ubiquitination	[2]
211	LTSLLSEKAKEFLME	ubiquitination	[2, 3]
213	SLLSEKAKEFLMENR	ubiquitination	[1, 2]
261	FKKDTTSKAIHSIFK	ubiquitination	[1]
268	KAIHSIFKNAIQLLQ	ubiquitination	[1]
277	AIQLLQEKGLVFQKD	ubiquitination	[1, 2, 3]
283	EKGLVFQKDDGFDNL	ubiquitination	[1, 2, 3]
314	IIQQDCQKPNHMEKG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. 

Sequence Annotation

 DNA_BIND 57 155 OB.  

Keyword

 3D-structure; Chromosome; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Telomere. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 368 AA 

Protein Sequence

Gene Ontology

 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0000784; C:nuclear chromosome, telomeric region; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0070188; C:Stn1-Ten1 complex; IEA:Compara.
 GO:0043047; F:single-stranded telomeric DNA binding; IDA:UniProtKB.
 GO:0045740; P:positive regulation of DNA replication; ISS:UniProtKB.
 GO:0010833; P:telomere maintenance via telomere lengthening; IMP:UniProtKB. 

Interpro

 IPR014647; CST_STN1.
 IPR015253; DUF1879_CST_STN1.
 IPR012340; NA-bd_OB-fold.
 IPR004365; NA-bd_OB_tRNA-helicase. 

Pfam

 PF09170; DUF1879
 PF01336; tRNA_anti 

SMART

  

PROSITE

  

PRINTS