| Tag | Content |
|---|
| CPLM ID | CPLM-006612 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sedoheptulose 1,7-bisphosphatase |
Protein Synonyms/Alias | |
Gene Name | SHB17 |
Gene Synonyms/Alias | YKR043C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 217 | DDTVPYVKLESYRHL | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Sedoheptulose 1,7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1,7-bisphosphate (SBP), which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1,6-bisphosphatase activity in vitro, but this is probably not biologically relevant, since deletion does not affect fructose 1,6-biphosphate (FBP) levels. |
Sequence Annotation | REGION 24 25 Substrate.
REGION 99 102 Substrate.
REGION 176 181 Substrate.
ACT_SITE 13 13 Tele-phosphohistidine intermediate.
ACT_SITE 176 176
BINDING 12 12 Substrate.
BINDING 69 69 Substrate.
BINDING 181 181 Substrate.
BINDING 244 244 Substrate. |
Keyword | 3D-structure; Carbohydrate metabolism; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Oxidoreductase; Reference proteome; Ribosome biogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 271 AA |
Protein Sequence | MPSLTPRCII VRHGQTEWSK SGQYTGLTDL PLTPYGEGQM LRTGESVFRN NQFLNPDNIT 60
YIFTSPRLRA RQTVDLVLKP LSDEQRAKIR VVVDDDLREW EYGDYEGMLT REIIELRKSR 120
GLDKERPWNI WRDGCENGET TQQIGLRLSR AIARIQNLHR KHQSEGRASD IMVFAHGHAL 180
RYFAAIWFGL GVQKKCETIE EIQNVKSYDD DTVPYVKLES YRHLVDNPCF LLDAGGIGVL 240
SYAHHNIDEP ALELAGPFVS PPEEESQHGD V 271 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. GO:0050278; F:sedoheptulose-bisphosphatase activity; IDA:SGD. GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW. GO:0046390; P:ribose phosphate biosynthetic process; IDA:SGD. GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. |
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PRINTS | |