UniProt Accession

 FUT8_HUMAN; Q9BYC5; B4DFS7; G3V5N0; O00235; Q9BYC6; Q9P2U5; Q9P2U6 

Genbank Protein ID

 D89289; AH005745; Y17979; Y17976; Y17977; Y17978; AB049828; AB049740; AB032573; AB032573; AK294242; AL109847; AL161871; AL355840; AL359236 

Genbank Nucleotide ID

 BAA19764.1; AAB92372.2; CAA76988.1; CAA76985.1; CAA76986.1; CAA76987.1; BAB40975.1; BAB40929.2; BAA92859.2; BAA92858.1; BAG57538.1 

Protein Name

 Alpha-(1,6)-fucosyltransferase 

Protein Synonyms/Alias

 Alpha1-6FucT; Fucosyltransferase 8; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase 

Gene Name

 FUT8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	ELSKILAKLERLKQQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. 

Sequence Annotation

 DOMAIN 206 493 GT23.
 DOMAIN 502 563 SH3.
 REGION 365 366 Important for donor substrate binding.
 MOTIF 299 305 SH3-binding (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Glycosyltransferase; Golgi apparatus; Membrane; Polymorphism; Reference proteome; SH3 domain; SH3-binding; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 575 AA 

Protein Sequence

Gene Ontology

 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008424; F:glycoprotein 6-alpha-L-fucosyltransferase activity; TAS:UniProtKB.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0001701; P:in utero embryonic development; NAS:UniProtKB.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:Compara.
 GO:0042355; P:L-fucose catabolic process; NAS:UniProtKB.
 GO:0006491; P:N-glycan processing; TAS:UniProtKB.
 GO:0009312; P:oligosaccharide biosynthetic process; TAS:ProtInc.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0033578; P:protein glycosylation in Golgi; IEA:InterPro.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
 GO:0043112; P:receptor metabolic process; IEA:Compara.
 GO:0007585; P:respiratory gaseous exchange; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara. 

Interpro

 IPR015827; Alpha1_6FUT_euk.
 IPR027350; GT23_dom.
 IPR001452; SH3_domain. 

Pfam

  

SMART

 SM00326; SH3 

PROSITE

 PS51659; GT23
 PS50002; SH3 

PRINTS