| Tag | Content |
|---|
| CPLM ID | CPLM-002661 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | D-alanyl-D-alanine carboxypeptidase DacC |
Protein Synonyms/Alias | DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 |
Gene Name | dacC |
Gene Synonyms/Alias | b0839; JW0823 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 95 | TDMVTVGKDAWATGN | acetylation | [1] | | 214 | EKEFTFNKIRQPNRN | acetylation | [1] | | 292 | FETVTPIKPDATFVT | acetylation | [1] | | 331 | RGQLKNLKASYTLTE | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. |
Sequence Annotation | ACT_SITE 66 66 Acyl-ester intermediate (By similarity).
ACT_SITE 69 69 Proton acceptor (By similarity).
ACT_SITE 132 132 By similarity.
BINDING 235 235 Substrate (By similarity). |
Keyword | 3D-structure; Carboxypeptidase; Cell inner membrane; Cell membrane; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Direct protein sequencing; Hydrolase; Membrane; Peptidoglycan synthesis; Protease; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 400 AA |
Protein Sequence | MTQYSSLLRG LAAGSAFLFL FAPTAFAAEQ TVEAPSVDAR AWILMDYASG KVLAEGNADE 60
KLDPASLTKI MTSYVVGQAL KADKIKLTDM VTVGKDAWAT GNPALRGSSV MFLKPGDQVS 120
VADLNKGVII QSGNDACIAL ADYVAGSQES FIGLMNGYAK KLGLTNTTFQ TVHGLDAPGQ 180
FSTARDMALL GKALIHDVPE EYAIHKEKEF TFNKIRQPNR NRLLWSSNLN VDGMKTGTTA 240
GAGYNLVASA TQGDMRLISV VLGAKTDRIR FNESEKLLTW GFRFFETVTP IKPDATFVTQ 300
RVWFGDKSEV NLGAGEAGSV TIPRGQLKNL KASYTLTEPQ LTAPLKKGQV VGTIDFQLNG 360
KSIEQRPLIV MENVEEGGFF GRVWDFVMMK FHQWFGSWFS 400 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:EcoliWiki. GO:0004180; F:carboxypeptidase activity; IDA:EcoCyc. GO:0008658; F:penicillin binding; IDA:EcoCyc. GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:EC. GO:0009252; P:peptidoglycan biosynthetic process; IDA:EcoCyc. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0008360; P:regulation of cell shape; IGI:EcoCyc. GO:0042493; P:response to drug; IMP:EcoCyc. |
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Pfam | |
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PRINTS | |