CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001901
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-cell surface glycoprotein CD4 
Protein Synonyms/Alias
 T-cell surface antigen T4/Leu-3; CD4 
Gene Name
 CD4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
453QCPHRFQKTCSPI**ubiquitination[1, 2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. 
Sequence Annotation
 DOMAIN 26 125 Ig-like V-type.
 DOMAIN 126 203 Ig-like C2-type 1.
 DOMAIN 204 317 Ig-like C2-type 2.
 DOMAIN 318 374 Ig-like C2-type 3.
 REGION 427 455 HIV-1 Vpu-susceptibility domain.
 LIPID 419 419 S-palmitoyl cysteine.
 LIPID 422 422 S-palmitoyl cysteine.
 CARBOHYD 296 296 N-linked (GlcNAc...).
 CARBOHYD 325 325 N-linked (GlcNAc...).
 DISULFID 41 109
 DISULFID 155 184
 DISULFID 328 370  
Keyword
 3D-structure; Adaptive immunity; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 458 AA 
Protein Sequence
MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK 60
ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL 120
LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG 180
TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW 240
QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA 300
LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV 360
LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI VLGGVAGLLL FIGLGIFFCV 420
RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR FQKTCSPI 458 
Gene Ontology
 GO:0005769; C:early endosome; TAS:Reactome.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0042101; C:T cell receptor complex; NAS:UniProtKB.
 GO:0015026; F:coreceptor activity; NAS:UniProtKB.
 GO:0005201; F:extracellular matrix structural constituent; NAS:UniProtKB.
 GO:0042289; F:MHC class II protein binding; NAS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0001816; P:cytokine production; IEA:Compara.
 GO:0050829; P:defense response to Gram-negative bacterium; IEA:Compara.
 GO:0030260; P:entry into host cell; TAS:Reactome.
 GO:0006948; P:induction by virus of host cell-cell fusion; IDA:UniProtKB.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0032507; P:maintenance of protein location in cell; IDA:MGI.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Compara.
 GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; NAS:UniProtKB.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0045860; P:positive regulation of protein kinase activity; IDA:UniProtKB.
 GO:0045234; P:protein palmitoleylation; IDA:MGI.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0031295; P:T cell costimulation; TAS:Reactome.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
 GO:0045058; P:T cell selection; IDA:UniProtKB.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB. 
Interpro
 IPR000973; Ag_CD4.
 IPR015274; CD4-extracel.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR008424; Ig_C2-set.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr.
 IPR021963; Tcell_CD4_Cterm. 
Pfam
 PF05790; C2-set
 PF09191; CD4-extracel
 PF12104; Tcell_CD4_Cterm
 PF07686; V-set 
SMART
 SM00409; IG
 SM00406; IGv 
PROSITE
 PS50835; IG_LIKE 
PRINTS
 PR00692; CD4TCANTIGEN.