UniProt Accession

 H7C314_HUMAN; H7C314 

Genbank Protein ID

 AP000487 

Genbank Nucleotide ID

  

Protein Name

 Src substrate cortactin 

Protein Synonyms/Alias

  

Gene Name

 CTTN 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	ASHGYGGKFGVEQDR	acetylation	[1]
69	ASHGYGGKFGVEQDR	ubiquitination	[2]
89	VGHEYQSKLSKHCSQ	acetylation	[1]
106	SVRGFGGKFGVQMDR	ubiquitination	[2]
126	VGFEYQGKTEKHASQ	acetylation	[1]
126	VGFEYQGKTEKHASQ	ubiquitination	[2]
134	TEKHASQKDYSSGFG	acetylation	[1]
143	YSSGFGGKYGVQADR	ubiquitination	[2]
153	VQADRVDKSAVGFDY	ubiquitination	[2]
163	VGFDYQGKTEKHESQ	ubiquitination	[2]
180	YSKGFGGKYGIDKDK	ubiquitination	[2]
190	IDKDKVDKSAVGFEY	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0030027; C:lamellipodium; IEA:InterPro.
 GO:0001726; C:ruffle; IEA:InterPro. 

Interpro

 IPR015503; Cortactin.
 IPR003134; Hs1_Cortactin. 

Pfam

 PF02218; HS1_rep 

SMART

  

PROSITE

 PS51090; CORTACTIN 

PRINTS