CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023955
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interleukin-1 receptor-associated kinase 3 
Protein Synonyms/Alias
 IRAK-3; IL-1 receptor-associated kinase M; IRAK-M 
Gene Name
 IRAK3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
192QNLTYAVKLFKQEKKubiquitination[1]
379RVVLDDPKHIQLRDLubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). 
Sequence Annotation
 DOMAIN 41 106 Death.
 DOMAIN 165 452 Protein kinase.
 NP_BIND 171 179 ATP (By similarity).
 NP_BIND 295 298 ATP (By similarity).
 BINDING 192 192 ATP (By similarity).
 BINDING 311 311 ATP (By similarity).
 MOD_RES 467 467 Phosphoserine.  
Keyword
 Alternative splicing; Asthma; ATP-binding; Complete proteome; Kinase; Magnesium; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 596 AA 
Protein Sequence
MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK 60
YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNYGAVLS PSEKSYQEGG 120
FPNILFKETA NVTVDNVLIP EHNEKGILLK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY 180
RVEIQNLTYA VKLFKQEKKM QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI 240
YPYMRNGTLF DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL 300
LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF 360
GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL SFLDKKVPPC PRNFSAKLFC 420
LAGRCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE 480
DDESQNNNLL PSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE 540
ESWFPKYIVP SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE 596 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:BHF-UCL.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IC:BHF-UCL.
 GO:0045824; P:negative regulation of innate immune response; ISS:BHF-UCL.
 GO:0032695; P:negative regulation of interleukin-12 production; IMP:BHF-UCL.
 GO:0032715; P:negative regulation of interleukin-6 production; IMP:BHF-UCL.
 GO:0010936; P:negative regulation of macrophage cytokine production; ISS:BHF-UCL.
 GO:0043407; P:negative regulation of MAP kinase activity; IMP:BHF-UCL.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.
 GO:0042177; P:negative regulation of protein catabolic process; IMP:BHF-UCL.
 GO:0043242; P:negative regulation of protein complex disassembly; IMP:BHF-UCL.
 GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:BHF-UCL.
 GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:BHF-UCL.
 GO:0010933; P:positive regulation of macrophage tolerance induction; ISS:BHF-UCL.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0043330; P:response to exogenous dsRNA; ISS:BHF-UCL.
 GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.
 GO:0032494; P:response to peptidoglycan; ISS:BHF-UCL.
 GO:0009615; P:response to virus; IC:BHF-UCL. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom. 
Pfam
 PF00531; Death
 PF00069; Pkinase 
SMART
 SM00005; DEATH 
PROSITE
 PS50017; DEATH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS