CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014002
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative DNA repair and recombination protein RAD26-like 
Protein Synonyms/Alias
  
Gene Name
 RAD26L 
Gene Synonyms/Alias
 C9orf102 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
505PDFVQKSKDAAFETLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 DOMAIN 146 332 Helicase ATP-binding.
 DOMAIN 523 673 Helicase C-terminal.
 NP_BIND 159 166 ATP (By similarity).
 MOTIF 283 286 DEAH box.  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 712 AA 
Protein Sequence
MQPGSAPPPG RMDPSAPQPR AETSGKDIWH PGERCLAPSP DNGKLCEASI KSITVDENGK 60
SFAVVLYADF QERKIPLKQL QEVKFVKDCP RNLIFDDEDL EKPYFPNRKF PSSSVAFKLS 120
DNGDSIPYTI NRYLRDYQRE GTRFLYGHYI HGGGCILGDD MGLGKTVQVI SFLAAVLHKK 180
GTREDIENNM PEFLLRSMKK EPLSSTAKKM FLIVAPLSVL YNWKDELDTW GYFRVTVLHG 240
NRKDNELIRV KQRKCEIALT TYETLRLCLD ELNSLEWSAV IVDEAHRIKN PKARVTEVMK 300
ALKCNVRIGL TGTILQNNMK ELWCVMDWAV PGLLGSGTYF KKQFSDPVEH GQRHTATKRE 360
LATGRKAMQR LAKKMSGWFL RRTKTLIKDQ LPKKEDRMVY CSLTDFQKAV YQTVLETEDV 420
TLILQSSEPC TCRSGQKRRN CCYKTNSHGE TVKTLYLSYL TVLQKVANHV ALLQAASTSK 480
QQETLIKRIC DQVFSRFPDF VQKSKDAAFE TLSDPKYSGK MKVLQQLLNH CRKNRDKVLL 540
FSFSTKLLDV LQQYCMASGL DYRRLDGSTK SEERLKIVKE FNSTQDVNIC LVSTMAGGLG 600
LNFVGANVVV LFDPTWNPAN DLQAIDRAYR IGQCRDVKVL RLISLGTVEE IMYLRQIYKQ 660
QLHCVVVGSE NAKRYFEAVQ GSKEHQGELF GIHNLFKFRS QGSCLTKDIL EV 712 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW. 
Interpro
 IPR002464; DNA/RNA_helicase_DEAH_CS.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF00271; Helicase_C
 PF00176; SNF2_N 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00690; DEAH_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS