CPLM-001257

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001257

UniProt Accession

RA51D_HUMAN; O75771; B4DJU7; E1P637; O43537; O60355; O75196; O75847; O75848; O76073; O76085; O94908; Q9UFU5

Genbank Protein ID

Y15572; AF034956; AB013341; AB016223; AB016224; AB016225; AB018360; AB018361; AB018362; AB018363; AB020412; AY623116; AK296241; AC022916; CH471147; CH471147; CH471147; BC014422; AL117459

Genbank Nucleotide ID

CAA75681.1; AAC39719.1; BAA25914.1; BAA31747.1; BAA31748.1; BAA31749.1; BAA33779.1; BAA33780.1; BAA33781.1; BAA33782.1; BAA34690.1; AAT38112.1; BAG58959.1; EAW80181.1; EAW80184.1; EAW80196.1; AAH14422.1; CAB55937.1

Protein Name

DNA repair protein RAD51 homolog 4

Protein Synonyms/Alias

R51H3; RAD51 homolog D; RAD51-like protein 3; TRAD

Gene Name

RAD51D

Gene Synonyms/Alias

RAD51L3

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
42	DLEEVAQKCGLSYKT	ubiquitination	[1]
281	DRDSGRLKPALGRSW	ubiquitination	[1]
317	RRMACLAKSSRQPTG	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Sequence Annotation

NP_BIND 107 114 ATP (Potential).
REGION 1 83 Preferencially binds ssDNA.

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

328 AA

Protein Sequence

MGVLRVGLCP GLTEEMIQLL RSHRIKTVVD LVSADLEEVA QKCGLSYKTW RAHSSGNLGG 60
LQLPQVPAGR SWSGVRNALK KAGLGHGGTD GLSLNAFDER GTAVSTSRLD KLLDAGLYTG 120
EVTEIVGGPG SGKTQVCLCM AANVAHGLQQ NVLYVDSNGG LTASRLLQLL QAKTQDEEEQ 180
AEALRRIQVV HAFDIFQMLD VLQELRGTVA QQVTGSSGTV KVVVVDSVTA VVSPLLGGQQ 240
REGLALMMQL ARELKTLARD LGMAVVVTNH ITRDRDSGRL KPALGRSWSF VPSTRILLDT 300
IEGAGASGGR RMACLAKSSR QPTGFQEMVD IGTWGTSEQS ATLQGDQT 348

Gene Ontology

GO:0005634; C:nucleus; TAS:ProtInc.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; TAS:ProtInc.
GO:0008094; F:DNA-dependent ATPase activity; IEA:InterPro.
GO:0006281; P:DNA repair; TAS:ProtInc.
GO:0007131; P:reciprocal meiotic recombination; TAS:ProtInc.

Interpro

IPR003593; AAA+_ATPase.
IPR013632; DNA_recomb/repair_Rad51_C.
IPR016467; DNA_recomb/repair_RecA-like.
IPR020588; DNA_recomb_RecA/RadB_ATP-bd.
IPR027417; P-loop_NTPase.

Pfam

PF08423; Rad51

SMART

SM00382; AAA

PROSITE

PS50162; RECA_2

PRINTS