UniProt Accession

 AADAT_HUMAN; Q8N5Z0; B3KP84; Q9UL02 

Genbank Protein ID

 AF097994; AF481738; AK055952; BC031068 

Genbank Nucleotide ID

 AAF04623.1; AAM09683.1; BAG51596.1; AAH31068.1 

Protein Name

 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 

Protein Synonyms/Alias

 KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II 

Gene Name

 AADAT 

Gene Synonyms/Alias

 KAT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	DILSRGPKSMISLAG	acetylation	[1]
49	NPNMFPFKTAVITVE	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). 

Sequence Annotation

 BINDING 20 20 Substrate.
 BINDING 74 74 Substrate.
 BINDING 142 142 Substrate.
 BINDING 202 202 Substrate.
 BINDING 399 399 Substrate.
 MOD_RES 263 263 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Alternative splicing; Aminotransferase; Complete proteome; Mitochondrion; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 425 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0047536; F:2-aminoadipate transaminase activity; IDA:UniProtKB.
 GO:0016212; F:kynurenine-oxoglutarate transaminase activity; IDA:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:Compara.
 GO:0006103; P:2-oxoglutarate metabolic process; IDA:UniProtKB.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0006536; P:glutamate metabolic process; IDA:UniProtKB.
 GO:0033512; P:L-lysine catabolic process to acetyl-CoA via saccharopine; IEA:UniProtKB-UniPathway.
 GO:0006554; P:lysine catabolic process; TAS:Reactome.
 GO:0006569; P:tryptophan catabolic process; TAS:Reactome.
 GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:Compara. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

  

PRINTS