UniProt Accession

 PISD_HUMAN; Q9UG56; B1AKM7; O43207; O95535; Q6IC28; Q96GQ2; Q9UGA9 

Genbank Protein ID

 CR456540; AL050371; AL096768; AL096768; AL031255; AL031255; AL096768; CH471095; BC001482; BC009315; AF035304 

Genbank Nucleotide ID

 CAG30426.1; CAB43678.2; CAB56394.1; CAI23032.1; CAI23032.1; CAI22447.1; CAI22447.1; EAW59984.1; AAH01482.1; AAH09315.1; AAB88186.1 

Protein Name

 Phosphatidylserine decarboxylase proenzyme 

Protein Synonyms/Alias

 Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain 

Gene Name

 PISD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	HWEVALYKSVPTRLL	ubiquitination	[1]
201	ILNFGQVKNCEVEQV	ubiquitination	[1]
209	NCEVEQVKGVTYSLE	ubiquitination	[1]
240	AASCDSFKNQLVTRE	ubiquitination	[1]
296	PGMARWIKELFCHNE	ubiquitination	[2]
346	TNSPRHSKGSYNDFS	ubiquitination	[1, 2, 3]
395	KDFNFQLKTGQKIRF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 MOD_RES 378 378 Pyruvic acid (Ser) (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Decarboxylase; Lipid biosynthesis; Lipid metabolism; Lyase; Mitochondrion; Phospholipid biosynthesis; Phospholipid metabolism; Pyruvate; Reference proteome; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 409 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:LIFEdb.
 GO:0004609; F:phosphatidylserine decarboxylase activity; IEA:EC.
 GO:0006646; P:phosphatidylethanolamine biosynthetic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR003817; PS_Dcarbxylase.
 IPR005221; PS_decarb. 

Pfam

 PF02666; PS_Dcarbxylase 

SMART

  

PROSITE

  

PRINTS