UniProt Accession

 SYPH_RAT; P07825; Q499R3 

Genbank Protein ID

 X06177; X06388; M58396; M58402; M58401; M58399; BC099798; X06655 

Genbank Nucleotide ID

 CAA29543.1; CAA29685.1; AAA42196.1; AAA42196.1; AAA42196.1; AAA42196.1; AAH99798.1; CAA29854.1 

Protein Name

 Synaptophysin 

Protein Synonyms/Alias

 Major synaptic vesicle protein p38 

Gene Name

 Syp 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
163	AKGLSDVKMATDPEN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). 

Sequence Annotation

 DOMAIN 15 222 MARVEL.
 REGION 249 298 Repeats, Gly-rich.
 MOD_RES 75 75 Phosphotyrosine (By similarity).
 MOD_RES 221 221 Phosphothreonine (Potential).
 MOD_RES 273 273 Phosphotyrosine (Potential).
 MOD_RES 289 289 Phosphotyrosine (Potential).
 CARBOHYD 53 53 N-linked (GlcNAc...) (Potential).  

Keyword

 Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 307 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0060076; C:excitatory synapse; IDA:BHF-UCL.
 GO:0030285; C:integral to synaptic vesicle membrane; TAS:RGD.
 GO:0044306; C:neuron projection terminus; IDA:RGD.
 GO:0048786; C:presynaptic active zone; IEA:Compara.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0017075; F:syntaxin-1 binding; IDA:MGI.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0006897; P:endocytosis; IMP:UniProtKB.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0048168; P:regulation of neuronal synaptic plasticity; NAS:RGD.
 GO:2000474; P:regulation of opioid receptor signaling pathway; IDA:UniProtKB.
 GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IEA:Compara. 

Interpro

 IPR008253; Marvel.
 IPR021128; MARVEL-like_dom.
 IPR001285; Synaptophysin/porin. 

Pfam

 PF01284; MARVEL 

SMART

  

PROSITE

 PS51225; MARVEL
 PS00604; SYNAPTOP 

PRINTS

 PR00220; SYNAPTOPHYSN.