CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021566
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family member 17 
Protein Synonyms/Alias
  
Gene Name
 TBC1D17 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23YLHTSAKKYQDRDSLubiquitination[1, 2]
65TQILFSKKDSSGGDSubiquitination[2]
303LQQVPELKNRIFSGGubiquitination[2]
351TDEYFRMKLQWKSVSubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May act as a GTPase-activating protein for Rab family protein(s). 
Sequence Annotation
 DOMAIN 310 520 Rab-GAP TBC.  
Keyword
 Alternative splicing; Complete proteome; GTPase activation; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 648 AA 
Protein Sequence
MEGAGYRVVF EKGGVYLHTS AKKYQDRDSL IAGVIRVVEK DNDVLLHWAP VEEAGDSTQI 60
LFSKKDSSGG DSCASEEEPT FDPDYEPDWA VISTVRPQLC HSEPTRGAEP SCPQGSWAFS 120
VSLGELKSIR RSKPGLSWAY LVLVTQAGGS LPALHFHRGG TRALLRVLSR YLLLASSPQD 180
SRLYLVFPHD SSALSNSFHH LQLFDQDSSN VVSRFLQDPY STTFSSFSRV TNFFRGALQP 240
QPEGAASDLP PPPDDEPEPG FEVISCVELG PRPTVERGPP VTEEEWARHV GPEGRLQQVP 300
ELKNRIFSGG LSPSLRREAW KFLLGYLSWE GTAEEHKAHI RKKTDEYFRM KLQWKSVSPE 360
QERRNSLLHG YRSLIERDVS RTDRTNKFYE GPENPGLGLL NDILLTYCMY HFDLGYVQGM 420
SDLLSPILYV IQNEVDAFWC FCGFMELVQG NFEESQETMK RQLGRLLLLL RVLDPLLCDF 480
LDSQDSGSLC FCFRWLLIWF KREFPFPDVL RLWEVLWTGL PGPNLHLLVA CAILDMERDT 540
LMLSGFGSNE ILKHINELTM KLSVEDVLTR AEALHRQLTA CPELPHNVQE ILGLAPPAEP 600
HSPSPTASPL PLSPTRAPPT PPPSTDTAPQ PDSSLEILPE EEDEGADS 648 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR021935; DUF3548.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF12068; DUF3548
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS