CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044389
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA replication ATP-dependent helicase/nuclease DNA2 
Protein Synonyms/Alias
  
Gene Name
 DNA2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1123LNHLNSEKLIIDLPSubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1146 AA 
Protein Sequence
MKTPCIPSPK QGSKGRGQSP AAQVRGPTWN APAREGRPGA GHLGHLRVGA CARGAQARAF 60
FPFLSFLCYP RFRCLFCLQF AIPASRMEQL NELELLMEKS FWEEAELPAE LFQKKVVASF 120
PRTVLSTGMD NRYLVLAVNT VQNKEGNCEK RLVITASQSL ENKELCILRN DWCSVPVEPG 180
DIIHLEGDCT SDTWIIDKDF GYLILYPDML ISGTSIASSI RCMRRAVLSE TFRSSDPATR 240
QMLIGTVLHE VFQKAINNSF APEKLQELAF QTIQEIRHLK EMYRLNLSQD EIKQEVEDYL 300
PSFCKWAGDF MHKNTSTDFP QMQLSLPSDN SKDNSTCNIE VVKPMDIEES IWSPRFGLKG 360
KIDVTVGVKI HRGYKTKYKI MPLELKTGKE SNSIEHRSQV VLYTLLSQER RADPEAGLLL 420
YLKTGQMYPV PANHLDKREL LKLRNQMAFS LFHRISKSAT RQKTQLASLP QIIEEEKTCK 480
YCSQIGNCAL YSRAVEQQMD CSSVPIVMLP KIEEETQHLK QTHLEYFSLW CLMLTLESQS 540
KDNKKNHQNI WLMPASEMEK SGSCIGNLIR MEHVKIVCDG QYLHNFQCKH GAIPVTNLMA 600
GDRVIVSGEE RSLFALSRGY VKEINMTTVT CLLDRNLSVL PESTLFRLDQ EEKNCDIDTP 660
LGNLSKLMEN TFVSKKLRDL IIDFREPQFI SYLSSVLPHD AKDTVACILK GLNKPQRQAM 720
KKVLLSKDYT LIVGMPGTGK TTTICTLVRI LYACGFSVLL TSYTHSAVDN ILLKLAKFKI 780
GFLRLGQIQK VHPAIQQFTE QEICRSKSIK SLALLEELYN SQLIVATTCM GINHPIFSRK 840
IFDFCIVDEA SQISQPICLG PLFFSRRFVL VGDHQQLPPL VLNREARALG MSESLFKRLE 900
QNKSAVVQLT VQYRMNSKIM SLSNKLTYEG KLECGSDKVA NAVINLRHFK DVKLELEFYA 960
DYSDNPWLMG VFEPNNPVCF LNTDKVPAPE QVEKGGVSNV TEAKLIVFLT SIFVKAGCSP 1020
SDIGIIAPYR QQLKIINDLL ARSIGMVEVN TVDKYQGRDK SIVLVSFVRS NKDGTVGELL 1080
KDWRRLNVAI TRAKHKLILL GCVPSLNCYP PLEKLLNHLN SEKLIIDLPS REHESLCHIL 1140
GDFQRE 1146 
Gene Ontology
 GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
 GO:0043142; F:single-stranded DNA-dependent ATPase activity; IEA:InterPro.
 GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro. 
Interpro
 IPR026851; Dna2.
 IPR014808; DNA_replication_fac_Dna2_N.
 IPR027417; P-loop_NTPase. 
Pfam
 PF08696; Dna2 
SMART
  
PROSITE
  
PRINTS