CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017549
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein POC5 
Protein Synonyms/Alias
 Protein of centriole 5; hPOC5 
Gene Name
 POC5 
Gene Synonyms/Alias
 C5orf37 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
180NIISELSKWRLNFIDubiquitination[1, 2]
270RQDVYEGKLADQYYQubiquitination[2, 3]
297SVVQKQWKDVVERACubiquitination[2]
334SGALENAKAEIQRMQubiquitination[2, 3]
344IQRMQHEKEHFEDSMubiquitination[2]
384GIDSTNNKKEEYGPGubiquitination[2]
385IDSTNNKKEEYGPGVubiquitination[2]
481VVTSAQQKAGRTITAubiquitination[2]
522MSSVVVEKHHPVTVQubiquitination[2]
538IPQATAAKYPRTIHPacetylation[4]
538IPQATAAKYPRTIHPubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Essential for the assembly of the distal half of centrioles, required for centriole elongation. 
Sequence Annotation
 REPEAT 142 173 Centrin-binding (CBR) 1.
 REPEAT 231 262 Centrin-binding (CBR) 2.
 REPEAT 263 295 Centrin-binding (CBR) 3.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 109 109 Phosphoserine.
 MOD_RES 538 538 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Cell cycle; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 575 AA 
Protein Sequence
MSSDEEKYSL PVVQNDSSRG SSVSSNLQEE YEELLHYAIV TPNIEPCASQ SSHPKGELVP 60
DVRISTIHDI LHSQGNNSEV RETAIEVGKG CDFHISSHSK TDESSPVLSP RKPSHPVMDF 120
FSSHLLADSS SPATNSSHTD AHEILVSDFL VSDENLQKME NVLDLWSSGL KTNIISELSK 180
WRLNFIDWHR MEMRKEKEKH AAHLKQLCNQ INELKELQKT FEISIGRKDE VISSLSHAIG 240
KQKEKIELMR TFFHWRIGHV RARQDVYEGK LADQYYQRTL LKKVWKVWRS VVQKQWKDVV 300
ERACQARAEE VCIQISNDYE AKVAMLSGAL ENAKAEIQRM QHEKEHFEDS MKKAFMRGVC 360
ALNLEAMTIF QNRNDAGIDS TNNKKEEYGP GVQGKEHSAH LDPSAPPMPL PVTSPLLPSP 420
PAAVGGASAT AVPSAASMTS TRAASASSVH VPVSALGAGS AATAASEEMY VPRVVTSAQQ 480
KAGRTITARI TGRCDFASKN RISSSLAIMG VSPPMSSVVV EKHHPVTVQT IPQATAAKYP 540
RTIHPESSTS ASRSLGTRSA HTQSLTSVHS IKVVD 575 
Gene Ontology
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS