CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015474
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PERQ amino acid-rich with GYF domain-containing protein 2 
Protein Synonyms/Alias
 GRB10-interacting GYF protein 2; Trinucleotide repeat-containing gene 15 protein 
Gene Name
 Gigyf2 
Gene Synonyms/Alias
 Kiaa0642; Perq2; Tnrc15 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
668LQQFQALKMRMSDQNubiquitination[1]
987QQQQQQQKLSGWGNVubiquitination[1]
996SGWGNVSKPAGTTKSubiquitination[1]
1090GFWDDAVKEVGPRNSubiquitination[1]
1109KNNASLSKSVGVSNRubiquitination[1]
1129EEEEKLLKLFQGVNKubiquitination[1]
1191LGDTSEAKEFAKQFLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. 
Sequence Annotation
 DOMAIN 534 582 GYF.
 REGION 548 564 Required for GRB10-binding.
 MOD_RES 25 25 Phosphothreonine.
 MOD_RES 26 26 Phosphoserine (By similarity).
 MOD_RES 30 30 Phosphoserine (By similarity).
 MOD_RES 140 140 Phosphoserine (By similarity).
 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 190 190 Phosphoserine (By similarity).
 MOD_RES 237 237 Phosphoserine (By similarity).
 MOD_RES 383 383 Phosphothreonine.
 MOD_RES 594 594 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1291 AA 
Protein Sequence
MAAETQTLNF GPEWLRALSS GGSITSPPLS PALPKYKLAD YRYGREEMLA LFLKDYKIPF 60
DLLEKEFLPI LQEEPLPPLA LVPFTEEEQR NFSMSVNSAA VLRLTGRGGG GGTVVGAPRG 120
RSSSRGRGRG RGECGFYQRS FDEVEGVFGR GGGREMHRSQ SWEERGDRRF EKPGRKDVGR 180
PNFEESGPTS VGRKHEFIRS ESENWRIFRE EQNGEDEDGG WRLAGSRRDG ERWRPHSPDG 240
PRSTGWREHM ERRRRFEFDF RDRDDERGYR RVRSGSGSID DDRDSLPEWC LEDAEEEMGT 300
FDSSGAFLSL KKVQKEPIPE EQEMDFRPVE EGEERSDSDS SHNEEAKEPD KTNRREGEKT 360
DRAGAEASEE VPQTSLSSAR PGTPSDHQPQ EATQFERKDE PKAEQVEKAE EENRSENSLS 420
AKVPSRGDET VPASQQPSTP LPPDTASPLL ILSPPVPTPS SASRPVETAA VEAPGMSSVS 480
TEPDDEEGLK HLEQQAEKMV AYLQDSALDD ERLTSKLQEH RAKGVSIPLM HEAMQKWYYK 540
DPQGEIQGPF NNQEMAEWFQ AGYFTMSLLV KRACDESFQP LGDIMKMWGR VPFSPGPAPP 600
PHMGELDQER LTRQQELTAL YQMQHLQYQQ FLIQQQYAQV LAQQQKAALS SQQQQQLALL 660
LQQFQALKMR MSDQNIIPSV TRSVSVPDTG SIWELQPAAS QPAVWEGGSV WDLPLDTTAP 720
GPSLEQLQQL EKAKAAKLEQ ERREAEMRAK REEEERKRQE ELRRQQEEIL RRQQEEERKR 780
REEEELARRK QEEALRRQRE QEIALRRQRE EEERQQQEEA LRRLEERRRE EEERRKQEEL 840
LRKQEEEAAK WAREEEEAQR RLEENRLRME EEAARLRHEE EERKRKELEL QRQKDLMRQR 900
QQQQEALRRL QQQQQQQQLA QMKLPSSSTW GQQSNTATCQ SQATLSLAEI QKLEEERERQ 960
LREEQRRQQR ELMKALQQQQ QQQQQQKLSG WGNVSKPAGT TKSLLEIQQE EARQMQKQQQ 1020
QQQQQQQQHQ QSNRARNSTH SNLHTSLGNS VWGSINTGPS NQWASELVSS IWSNADTKNS 1080
NMGFWDDAVK EVGPRNSTNK NKNNASLSKS VGVSNRQNKK VEEEEKLLKL FQGVNKAQDG 1140
FTQWCEQMLH ALNTANNLDV PTFVSFLKEV ESPYEVHDYT RAYLGDTSEA KEFAKQFLER 1200
RAKQKVNQQR QQQQQQQQQQ DSVWGMNHST LHSVFQTNQS NNQQSNFEAV QSGKKKKKQK 1260
MVRADPSLLG FSVNASSERL NMGEIETLDD Y 1291 
Gene Ontology
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0044267; P:cellular protein metabolic process; IMP:MGI.
 GO:0007631; P:feeding behavior; IMP:MGI.
 GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
 GO:0048009; P:insulin-like growth factor receptor signaling pathway; IMP:MGI.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0050881; P:musculoskeletal movement; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI. 
Interpro
 IPR003169; GYF. 
Pfam
 PF02213; GYF 
SMART
 SM00444; GYF 
PROSITE
 PS50829; GYF 
PRINTS