CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006629
UniProt Accession
Genbank Protein ID
 M90459 
Genbank Nucleotide ID
Protein Name
 Antigen peptide transporter 2 
Protein Synonyms/Alias
 APT2; ATP-binding cassette sub-family B member 3; Histocompatibility antigen modifier 2 
Gene Name
 Tap2 
Gene Synonyms/Alias
 Abcb3; Ham-2; Ham2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
244LGFFQETKTGELNSRubiquitination[1]
355EQEVSHYKEALERCRubiquitination[1]
449VFSYLDRKPNLPQPGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity). 
Sequence Annotation
 DOMAIN 151 434 ABC transmembrane type-1.
 DOMAIN 467 701 ABC transporter.
 NP_BIND 502 509 ATP (Potential).
 REGION 300 388 Involved in peptide-binding site (By
 REGION 413 432 Involved in peptide-binding site (By  
Keyword
 Adaptive immunity; ATP-binding; Complete proteome; Endoplasmic reticulum; Immunity; Membrane; Nucleotide-binding; Peptide transport; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 702 AA 
Protein Sequence
MALSYLRPWV SLLLADMALL GLLQGSLGNL LPQGLPGLWI EGTLRLGVLW GLLKVGELLG 60
LVGTLLPLLC LATPLFFSLR ALVGGTASTS VVRVASASWG WLLAGYGAVA LSWAVWAVLS 120
PAGVQEKEPG QENRTLMKRL LKLSRPDLPF LIAAFFFLVV AVWGETLIPR YSGRVIDILG 180
GDFDPDAFAS AIFFMCLFSV GSSFSAGCRG GSFLFTMSRI NLRIREQLFS SLLRQDLGFF 240
QETKTGELNS RLSSDTSLMS RWLPFNANIL LRSLVKVVGL YFFMLQVSPR LTFLSLLDLP 300
LTIAAEKVYN PRHQAVLKEI QDAVAKAGQV VREAVGGLQT VRSFGAEEQE VSHYKEALER 360
CRQLWWRRDL EKDVYLVIRR VMALGMQVLI LNCGVQQILA GEVTRGGLLS FLLYQEEVGQ 420
YVRNLVYMYG DMLSNVGAAE KVFSYLDRKP NLPQPGILAP PWLEGRVEFQ DVSFSYPRRP 480
EKPVLQGLTF TLHPGTVTAL VGPNGSGKST VAALLQNLYQ PTGGQLLLDG EPLTEYDHHY 540
LHRQVVLVGQ EPVLFSGSVK DNIAYGLRDC EDAQVMAAAQ AACADDFIGE MTNGINTEIG 600
EKGGQLAVGQ KQRLAIARAL VRNPRVLILD EATSALDAQC EQALQNWRSQ GDRTMLVIAH 660
RLHTVQNADQ VLVLKQGRLV EHDQLRDGQD VYAHLVQQRL EA 702 
Gene Ontology
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0042825; C:TAP complex; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042288; F:MHC class I protein binding; IBA:RefGenome.
 GO:0015421; F:oligopeptide-transporting ATPase activity; IBA:RefGenome.
 GO:0042605; F:peptide antigen binding; IBA:RefGenome.
 GO:0046978; F:TAP1 binding; IBA:RefGenome.
 GO:0046979; F:TAP2 binding; IBA:RefGenome.
 GO:0046980; F:tapasin binding; ISS:UniProtKB.
 GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI.
 GO:0002489; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; IDA:MGI.
 GO:0002481; P:antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IMP:MGI.
 GO:0002591; P:positive regulation of antigen processing and presentation of peptide antigen via MHC class I; IBA:RefGenome.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0002237; P:response to molecule of bacterial origin; IMP:MGI. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013306; ABC_B3.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005293; Ag_transporter2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS
 PR01897; TAP2PROTEIN.