CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041115
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG140437, isoform CRA_d 
Protein Synonyms/Alias
 Protein Myh2 
Gene Name
 Myh2 
Gene Synonyms/Alias
 mCG_140437 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
35QNRPFDAKTSVFVAEubiquitination[1]
44SVFVAEPKESFVKGTubiquitination[1]
237LEAFGNAKTVRNDNSubiquitination[1]
281SRVTFQLKAERSYHIubiquitination[1]
386DGTEVADKAAYLQGLubiquitination[1]
601TGWLDKNKDPLNETVubiquitination[1]
647AKKGAKKKGSSFQTVubiquitination[1]
751DSKKASEKLLGSIDIubiquitination[1]
764DIDHTQYKFGHTKVFubiquitination[1]
917ERCDQLIKTKIQLEAubiquitination[1]
919CDQLIKTKIQLEAKIubiquitination[1]
925TKIQLEAKIKEVTERubiquitination[1]
946INAELTAKKRKLEDEubiquitination[1]
983HATENKVKNLTEEMAubiquitination[1]
998GLDETIAKLTKEKKAubiquitination[1]
1004AKLTKEKKALQEAHQubiquitination[1]
1023DLQAEEDKVNTLTKAubiquitination[1]
1029DKVNTLTKAKIKLEQubiquitination[1]
1033TLTKAKIKLEQQVDDubiquitination[1]
1113AIGIQLQKKIKELQAubiquitination[1]
1172SAQIEMNKKREAEFQubiquitination[1]
1180KREAEFQKMRRDLEEubiquitination[1]
1201ATAATLRKKHADSVAubiquitination[1]
1247SNVETVSKAKGNLEKubiquitination[1]
1254KAKGNLEKMCRTLEDubiquitination[1]
1301FSRQLDEKEALVSQLubiquitination[1]
1312VSQLSRGKQAFTQQIubiquitination[1]
1323TQQIEELKRQLEEEVacetylation[2]
1323TQQIEELKRQLEEEVubiquitination[1]
1333LEEEVKAKNALAHALubiquitination[1]
1370ELQRALSKANSEVAQubiquitination[1]
1451AACAALDKKQRNFDKubiquitination[1]
1458KKQRNFDKILAEWKQubiquitination[1]
1464DKILAEWKQKYEETHubiquitination[1]
1466ILAEWKQKYEETHAEubiquitination[1]
1479AELEASQKEARSLGTubiquitination[1]
1490SLGTELFKMKNAYEEubiquitination[1]
1492GTELFKMKNAYEESLubiquitination[1]
1506LDQLETLKRENKNLQubiquitination[1]
1510ETLKRENKNLQQEISubiquitination[1]
1528EQIAEGGKRIHELEKubiquitination[1]
1576QLELNQVKSEIDRKIubiquitination[1]
1582VKSEIDRKIAEKDEEubiquitination[1]
1586IDRKIAEKDEEIDQLubiquitination[1]
1594DEEIDQLKRNHIRVVubiquitination[1]
1623NDAIRIKKKMEGDLNubiquitination[1]
1658RNTQGILKDTQLHLDubiquitination[1]
1675LRGQEDLKEQLAMVEubiquitination[1]
1707EQTERSRKIAEQELLubiquitination[1]
1734NTSLINTKKKLETDIubiquitination[1]
1735TSLINTKKKLETDISubiquitination[1]
1790SAHLERMKKNMEQTVubiquitination[1]
1791AHLERMKKNMEQTVKubiquitination[1]
1798KNMEQTVKDLQLRLDubiquitination[1]
1813EAEQLALKGGKKQIQubiquitination[1]
1816QLALKGGKKQIQKLEubiquitination[1]
1817LALKGGKKQIQKLEAubiquitination[1]
1838GEVESEQKRNAEAVKubiquitination[1]
1845KRNAEAVKGLRKHERubiquitination[1]
1855RKHERRVKELTYQTEubiquitination[1]
1877RLQDLVDKLQAKVKSubiquitination[1]
1881LVDKLQAKVKSYKRQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1942 AA 
Protein Sequence
MSSDAEMAVF GEAAPYLRKS EKERIEAQNR PFDAKTSVFV AEPKESFVKG TIQSKDAGKV 60
TVKTEAGATL TVKEDQIFPM NPPKYDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 120
LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE 180
SGAGKTVNTK RVIQYFATIA VTGDKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR 240
NDNSSRFGKF IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPEL 300
IEMLLITTNP YDYPFVSQGE ISVASIDDQE ELMATDSAID ILGFTNDEKV SIYKLTGAVM 360
HYGNMKFKQK QREEQAEPDG TEVADKAAYL QGLNSADLLK ALCYPRVKVG NEYVTKGQTV 420
EQVTNAVGAL AKAMYEKMFL WMVTRINQQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC 480
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE 540
CMFPKATDTS FKNKLYEQHL GKSANFQKPK VVKGKAEAHF SLIHYAGTVD YNITGWLDKN 600
KDPLNETVVG LYQKSSVKTL AYLFSGAQTA EAEASSGGAA KKGAKKKGSS FQTVSALFRE 660
NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL RCNGVLEGIR ICRKGFPSRI 720
LYADFKQRYK VLNASAIPEG QYIDSKKASE KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL 780
EEMRDDKLAQ LITRTQAMCR GFLARVEYQK MVERRESIFC IQYNIRAFMN VKHWPWMKLF 840
FKIKPLLKSA ETEKEMATMK EEFQKTKDDL AKSEAKRKEL EEKMVSLLKE KNDLQLQVQA 900
EAEGLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL EDECSELKKD 960
IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT KEKKALQEAH QQTLDDLQAE 1020
EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK LRMDLERAKR KLEGDLKLAQ ESIMDIENEK 1080
QQLDERLKKK EFEMSNLQSK IEDEQAIGIQ LQKKIKELQA RIEELEEEIE AERASRAKAE 1140
KQRSDLSREL EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR 1200
KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NVETVSKAKG NLEKMCRTLE 1260
DQVSELKSKE EEQQRLINDL TTQRGRLQTE SGEFSRQLDE KEALVSQLSR GKQAFTQQIE 1320
ELKRQLEEEV KAKNALAHAL QSSRHDCDLL REQYEEEQES KAELQRALSK ANSEVAQWRT 1380
KYETDAIQRT EELEEAKKKL AQRLQAAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMLDVE 1440
RTNAACAALD KKQRNFDKIL AEWKQKYEET HAELEASQKE ARSLGTELFK MKNAYEESLD 1500
QLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQV EQEKCELQAA LEEAEASLEH 1560
EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV VESMQSTLDA EIRSRNDAIR 1620
IKKKMEGDLN EMEIQLNHSN RMAAEALRNY RNTQGILKDT QLHLDDALRG QEDLKEQLAM 1680
VERRANLLQA EIEELRATLE QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD 1740
ISQIQGEMED IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNMEQTVKDL 1800
QLRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVESEQKRN AEAVKGLRKH ERRVKELTYQ 1860
TEEDRKNILR LQDLVDKLQA KVKSYKRQAE EAEEQSNTNL SKFRKIQHEL EEAEERADIA 1920
ESQVNKLRVK SREVHTKIIS EE 1942 
Gene Ontology
 GO:0031672; C:A band; IDA:MGI.
 GO:0005826; C:actomyosin contractile ring; IDA:MGI.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IMP:MGI.
 GO:0005859; C:muscle myosin complex; ISO:MGI.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0001778; P:plasma membrane repair; IMP:MGI.
 GO:0014823; P:response to activity; IDA:MGI. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR015650; Myosin_1/23/4/7/8/13/15.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.