CPLM-044787

Genbank Nucleotide ID

Mothers against decapentaplegic homolog 4

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
37	GESETFAKRAIESLV	acetylation	[1]
45	RAIESLVKKLKEKKD	acetylation	[2]
70	TNGAHPSKCVTIQRT	ubiquitination	[3]
113	KNELKHVKYCQYAFD	ubiquitination	[3, 4, 5]

[1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
[2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
[3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]

Functional Description

Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IEA:Compara.
GO:0005667; C:transcription factor complex; IEA:Compara.
GO:0003682; F:chromatin binding; IEA:Compara.
GO:0003677; F:DNA binding; IEA:Compara.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
GO:0008283; P:cell proliferation; IEA:Compara.
GO:0048589; P:developmental growth; IEA:Compara.
GO:0007492; P:endoderm development; IEA:Compara.
GO:0048859; P:formation of anatomical boundary; IEA:Compara.
GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
GO:0001701; P:in utero embryonic development; IEA:Compara.
GO:0007498; P:mesoderm development; IEA:Compara.
GO:0072133; P:metanephric mesenchyme morphogenesis; IEA:Compara.
GO:0060548; P:negative regulation of cell death; IEA:Compara.
GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
GO:0072134; P:nephrogenic mesenchyme morphogenesis; IEA:Compara.
GO:0014033; P:neural crest cell differentiation; IEA:Compara.
GO:0048663; P:neuron fate commitment; IEA:Compara.
GO:0060021; P:palate development; IEA:Compara.
GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Compara.
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Compara.
GO:0060391; P:positive regulation of SMAD protein import into nucleus; IEA:Compara.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
GO:0051098; P:regulation of binding; IEA:Compara.
GO:0051797; P:regulation of hair follicle development; IEA:Compara.
GO:0048733; P:sebaceous gland development; IEA:Compara.
GO:0032525; P:somite rostral/caudal axis specification; IEA:Compara.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara.

IPR013790; Dwarfin.
IPR003619; MAD_homology1_Dwarfin-type.
IPR013019; MAD_homology_MH1.