CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011217
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copper-transporting ATPase 1 
Protein Synonyms/Alias
 Copper pump 1; Menkes disease-associated protein 
Gene Name
 ATP7A 
Gene Synonyms/Alias
 MC1; MNK 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
936IKVVPGGKFPVDGRVubiquitination[1]
1552INSLLSDKRSLNSVVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells. 
Sequence Annotation
 DOMAIN 9 75 HMA 1.
 DOMAIN 172 238 HMA 2.
 DOMAIN 278 344 HMA 3.
 DOMAIN 378 444 HMA 4.
 DOMAIN 489 555 HMA 5.
 DOMAIN 565 631 HMA 6.
 REGION 1486 1500 PDZD11-binding.
 MOTIF 1487 1488 Endocytosis signal.
 ACT_SITE 1044 1044 4-aspartylphosphate intermediate (By
 METAL 1301 1301 Magnesium (By similarity).
 METAL 1305 1305 Magnesium (By similarity).
 MOD_RES 339 339 Phosphoserine.
 MOD_RES 1212 1212 Phosphothreonine (By similarity).
 CARBOHYD 686 686 N-linked (GlcNAc...) (Potential).
 CARBOHYD 975 975 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Copper; Copper transport; Cytoplasm; Disease mutation; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Neurodegeneration; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1500 AA 
Protein Sequence
MRKLSIRKRD NNLLKPSSAS SLGIAVSLGR PVLSRSSSGT VNLLEEVGLH IRDTAFSSTK 60
LLEAISTVSA QVEELAVHNE CYDPSMGVNS VTISVEGMTC NSCVWTIEQQ IGKVNGVHHI 120
KVSLEEKNAT IIYDPKLQTP KTLQEAIDDM GFDAVIHNPD PLPVLTDTLF LTVTASLTLP 180
WDHIQSTLLK TKGVTDIKIY PQKRTVAVTI IPSIVNANQI KELVPELSLD TGTLEKKSGA 240
CEDHSMAQAG EVVLKMKVEG MTCHSCTSTI EGKIGKLQGV QRIKVSLDNQ EATIVYQPHL 300
ISVEEMKKQI EAMGFPAFVK KQPKYLKLGA IDVERLKNTP VKSSEGSQQR SPSYTNDSTA 360
TFIIDGMHCK SCVSNIESTL SALQYVSSIV VSLENRSAIV KYNASSVTPE SLRKAIEAVS 420
PGLYRVSITS EVESTSNSPS SSSLQKIPLN VVSQPLTQET VINIDGMTCN SCVQSIEGVI 480
SKKPGVKSIR VSLANSNGTV EYDPLLTSPE TLRGAIEDMG FDATLSDTNE PLVVIAQPSS 540
EMPLLTSTNE FYTKGMTPVQ DKEEGKNSSK CYIQVTGMTC ASCVANIERN LRREEGIYSI 600
LVALMAGKAE VRYNPAVIQP PMIAEFIREL GFGATVIENA DEGDGVLELV VRGMTCASCV 660
HKIESSLTKH RGILYCSVAL ATNKAHIKYD PEIIGPRDII HTIESLGFEA SLVKKDRSAS 720
HLDHKREIRQ WRRSFLVSLF FCIPVMGLMI YMMVMDHHFA TLHHNQNMSK EEMINLHSSM 780
FLERQILPGL SVMNLLSFLL CVPVQFFGGW YFYIQAYKAL KHKTANMDVL IVLATTIAFA 840
YSLIILLVAM YERAKVNPIT FFDTPPMLFV FIALGRWLEH IAKGKTSEAL AKLISLQATE 900
ATIVTLDSDN ILLSEEQVDV ELVQRGDIIK VVPGGKFPVD GRVIEGHSMV DESLITGEAM 960
PVAKKPGSTV IAGSINQNGS LLICATHVGA DTTLSQIVKL VEEAQTSKAP IQQFADKLSG 1020
YFVPFIVFVS IATLLVWIVI GFLNFEIVET YFPGYNRSIS RTETIIRFAF QASITVLCIA 1080
CPCSLGLATP TAVMVGTGVG AQNGILIKGG EPLEMAHKVK VVVFDKTGTI THGTPVVNQV 1140
KVLTESNRIS HHKILAIVGT AESNSEHPLG TAITKYCKQE LDTETLGTCI DFQVVPGCGI 1200
SCKVTNIEGL LHKNNWNIED NNIKNASLVQ IDASNEQSST SSSMIIDAQI SNALNAQQYK 1260
VLIGNREWMI RNGLVINNDV NDFMTEHERK GRTAVLVAVD DELCGLIAIA DTVKPEAELA 1320
IHILKSMGLE VVLMTGDNSK TARSIASQVG ITKVFAEVLP SHKVAKVKQL QEEGKRVAMV 1380
GDGINDSPAL AMANVGIAIG TGTDVAIEAA DVVLIRNDLL DVVASIDLSR ETVKRIRINF 1440
VFALIYNLVG IPIAAGVFMP IGLVLQPWMG SAAMAASSVS VVLSSLFLKL YRKPTYESYE 1500
LPARSQIGQK SPSEISVHVG IDDTSRNSPK LGLLDRIVNY SRASINSLLS DKRSLNSVVT 1560
SEPDKHSLLV GDFREDDDTA L 1581 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0043005; C:neuron projection; ISS:UniProtKB.
 GO:0043025; C:neuronal cell body; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0030140; C:trans-Golgi network transport vesicle; IMP:HGNC.
 GO:0005524; F:ATP binding; TAS:HGNC.
 GO:0004008; F:copper-exporting ATPase activity; ISS:UniProtKB.
 GO:0016532; F:superoxide dismutase copper chaperone activity; ISS:UniProtKB.
 GO:0001568; P:blood vessel development; ISS:UniProtKB.
 GO:0001974; P:blood vessel remodeling; ISS:UniProtKB.
 GO:0051216; P:cartilage development; ISS:UniProtKB.
 GO:0006878; P:cellular copper ion homeostasis; IMP:UniProtKB.
 GO:0021702; P:cerebellar Purkinje cell differentiation; ISS:UniProtKB.
 GO:0030199; P:collagen fibril organization; ISS:UniProtKB.
 GO:0015677; P:copper ion import; ISS:UniProtKB.
 GO:0048813; P:dendrite morphogenesis; IEA:Compara.
 GO:0010273; P:detoxification of copper ion; ISS:UniProtKB.
 GO:0042417; P:dopamine metabolic process; ISS:UniProtKB.
 GO:0048251; P:elastic fiber assembly; ISS:UniProtKB.
 GO:0051542; P:elastin biosynthetic process; ISS:UniProtKB.
 GO:0042414; P:epinephrine metabolic process; ISS:UniProtKB.
 GO:0031069; P:hair follicle morphogenesis; ISS:UniProtKB.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007626; P:locomotory behavior; ISS:UniProtKB.
 GO:0048286; P:lung alveolus development; ISS:UniProtKB.
 GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
 GO:0048553; P:negative regulation of metalloenzyme activity; ISS:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
 GO:0042421; P:norepinephrine biosynthetic process; IEA:Compara.
 GO:0042415; P:norepinephrine metabolic process; ISS:UniProtKB.
 GO:0018205; P:peptidyl-lysine modification; ISS:UniProtKB.
 GO:0043473; P:pigmentation; ISS:UniProtKB.
 GO:0048554; P:positive regulation of metalloenzyme activity; ISS:UniProtKB.
 GO:0051353; P:positive regulation of oxidoreductase activity; IDA:UniProtKB.
 GO:0021860; P:pyramidal neuron development; ISS:UniProtKB.
 GO:0010468; P:regulation of gene expression; IEA:Compara.
 GO:0002082; P:regulation of oxidative phosphorylation; ISS:UniProtKB.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0019430; P:removal of superoxide radicals; ISS:UniProtKB.
 GO:0010041; P:response to iron(III) ion; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0042428; P:serotonin metabolic process; ISS:UniProtKB.
 GO:0043588; P:skin development; ISS:UniProtKB.
 GO:0042093; P:T-helper cell differentiation; ISS:UniProtKB.
 GO:0006568; P:tryptophan metabolic process; ISS:UniProtKB.
 GO:0006570; P:tyrosine metabolic process; IEA:Compara. 
Interpro
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR027256; Cation_transp_P-typ_ATPase_IB.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom.
 IPR017969; Heavy-metal-associated_CS.
 IPR006121; HeavyMe-assoc_HMA.
 IPR006122; HMA_Cu_ion-bd. 
Pfam
 PF00122; E1-E2_ATPase
 PF00403; HMA
 PF00702; Hydrolase 
SMART
  
PROSITE
 PS00154; ATPASE_E1_E2
 PS01047; HMA_1
 PS50846; HMA_2 
PRINTS
 PR00119; CATATPASE.