CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017525
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycerophosphodiester phosphodiesterase domain-containing protein 1 
Protein Synonyms/Alias
 Glycerophosphodiester phosphodiesterase 4 
Gene Name
 GDPD1 
Gene Synonyms/Alias
 GDE4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41KKQRFLSKHISHRGGubiquitination[1, 2, 3, 4, 5]
92VSHDENLKRATGVNVubiquitination[3]
304VMTDYPTKLRDFLHNubiquitination[3]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 DOMAIN 45 304 GDPD.
 METAL 72 72 Divalent metal cation (Potential).
 METAL 74 74 Divalent metal cation (Potential).
 METAL 87 87 Divalent metal cation (Potential).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
MSSTAAFYLL STLGGYLVTS FLLLKYPTLL HQRKKQRFLS KHISHRGGAG ENLENTMAAF 60
QHAVKIGTDM LELDCHITKD EQVVVSHDEN LKRATGVNVN ISDLKYCELP PYLGKLDVSF 120
QRACQCEGKD NRIPLLKEVF EAFPNTPINI DIKVNNNVLI KKVSELVKRY NREHLTVWGN 180
ANYEIVEKCY KENSDIPILF SLQRVLLILG LFFTGLLPFV PIREQFFEIP MPSIILKLKE 240
PHTMSRSQKF LIWLSDLLLM RKALFDHLTA RGIQVYIWVL NEEQEYKRAF DLGATGVMTD 300
YPTKLRDFLH NFSA 314 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006071; P:glycerol metabolic process; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 
Interpro
 IPR004129; GlyceroP-diester-Pdiesterase.
 IPR017946; PLC-like_Pdiesterase_TIM-brl. 
Pfam
 PF03009; GDPD 
SMART
  
PROSITE
  
PRINTS