CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inversin 
Protein Synonyms/Alias
  
Gene Name
 INVS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14RRANWMQKDLEEMTPubiquitination[1]
74EHVKLLIKHDSNIGIubiquitination[1]
214ETVKVFLKHPSVKDDubiquitination[1]
236SFMWAAGKGSDDVLRubiquitination[1]
294VDATDVMKHTPLFRAubiquitination[1, 2]
307RACEMGHKDVIQTLIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 988 AA 
Protein Sequence
MKLLLTRRAN WMQKDLEEMT PLHLTTRHRS PKCLALLLKF MAPGEVDTQD KNKQTALHWS 60
AYYNNPEHVK LLIKHDSNIG IPDVEGKIPL HWAANHKDPS AVHTVRCILD AAPTESLLNW 120
QDYEGRTPLH FAVADGNVTV VDVLTSYESC NITSYDNLFR TPLHWAALLG HAQIVHLLLE 180
RNKSGTIPSD SQGATPLHYA AQSNFAETVK VFLKHPSVKD DSDLEGRTSF MWAAGKGSDD 240
VLRTMLSLKS DIDINMADKY GGTALHAAAL SGHVSTVKLL LENNAQVDAT DVMKHTPLFR 300
ACEMGHKDVI QTLIKGGARV DLVDQDGHSL LHWAALGGNA DVCQILIENK INPNVQDYAG 360
RTPLQCAAYG GYINCMAVLM ENNADPNIQD KEGRTALHWS CNNGYLDAIK LLLDFAAFPN 420
QMENNEERYT PLDYALLGER HEVIQFMLEH GALSIAAIQD IAAFKIQAVY KGYKVRKAFR 480
DRKNLLMKHE QLRKDAAAKK REEENKRKEA EQQKGRRSPD SCRPQALPCL PSTQDVPSRQ 540
SRAPSKQPPA GNVAQGPEPR DSRGSPGGSL GGALQKEQHV SSDLQGTNSR RPNETAREHS 600
KGQSACVHFR PNEGSDGSRH PGVPSVEKSR GETAGDERCA KGKGFVKQPS CIRVAGPDEK 660
GEDSRRAAAS LPPHDSHWKP SRRHDTEPKA KCAPQKRRTQ ELRGGRCSPA GSSRPGSARG 720
EAVHAGQNPP HHRTPRNKVT QAKLTGGLYS HLPQSTEELR SGARRLETST LSEDFQVSKE 780
TDPAPGPLSG QSVNIDLLPV ELRLQIIQRE RRRKELFRKK NKAAAVIQRA WRSYQLRKHL 840
SHLRHMKQLG AGDVDRWRQE STALLLQVWR KELELKFPQT TAVSKAPKSP SKGTSGTKST 900
KHSVLKQIYG CSHEGKIHHP TRSVKASSVL RLNSGKAATA KQMVGKNMGK HFPLFHPQRQ 960
KTLEQIWPGF SNGHLISWDY YCSQHLSP 988 
Gene Ontology
  
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000048; IQ_motif_EF-hand-BS. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF00612; IQ 
SMART
 SM00248; ANK
 SM00015; IQ 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50096; IQ 
PRINTS
 PR01415; ANKYRIN.