CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014935
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Condensin-2 complex subunit H2 
Protein Synonyms/Alias
 Chromosome-associated protein H2; hCAP-H2; Kleisin-beta; Non-SMC condensin II complex subunit H2 
Gene Name
 NCAPH2 
Gene Synonyms/Alias
 CAPH2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
329PFDSLESKPFKKGRPubiquitination[1]
333LESKPFKKGRPYSVPubiquitination[1]
382DSRRLRRKGPSFADMubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May play a role in lineage-specific role in T-cell development (By similarity). 
Sequence Annotation
 MOD_RES 19 19 Phosphothreonine.
 MOD_RES 95 95 Phosphoserine.
 MOD_RES 96 96 Phosphoserine.
 MOD_RES 200 200 Phosphoserine.
 MOD_RES 208 208 Phosphoserine.
 MOD_RES 282 282 Phosphoserine.
 MOD_RES 284 284 Phosphoserine.
 MOD_RES 466 466 Phosphoserine.
 MOD_RES 492 492 Phosphoserine.  
Keyword
 Alternative splicing; Chromosome; Complete proteome; DNA condensation; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI 60
QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS 120
LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR 180
MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS 240
QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER 300
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ 360
DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA 420
EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA 480
TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL 540
VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP 600
SMAQP 605 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW. 
Interpro
 IPR009378; Condensin_II_H2-like. 
Pfam
 PF06278; DUF1032 
SMART
  
PROSITE
  
PRINTS