CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021428
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coiled-coil domain-containing protein 86 
Protein Synonyms/Alias
 Cytokine-induced protein with coiled-coil domain 
Gene Name
 CCDC86 
Gene Synonyms/Alias
 CYCLON 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
212VTGGFGAKKRKGSSSacetylation[1]
261FSQMLQDKPLRTSWQacetylation[1, 2, 3, 4]
261FSQMLQDKPLRTSWQubiquitination[5, 6]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 18 18 Phosphoserine.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 50 50 Phosphoserine.
 MOD_RES 58 58 Phosphoserine.
 MOD_RES 65 65 Phosphothreonine.
 MOD_RES 66 66 Phosphoserine.
 MOD_RES 69 69 Phosphoserine.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 91 91 Phosphoserine.
 MOD_RES 102 102 Phosphoserine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 128 128 Phosphoserine.
 MOD_RES 217 217 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MDTPLRRSRR LGGLRPESPE SLTSVSRTRR ALVEFESNPE ETREPGSPPS VQRAGLGSPE 60
RPPKTSPGSP RLQQGAGLES PQGQPEPGAA SPQRQQDLHL ESPQRQPEYS PESPRCQPKP 120
SEEAPKCSQD QGVLASELAQ NKEELTPGAP QHQLPPVPGS PEPYPGQQAP GPEPSQPLLE 180
LTPRAPGSPR GQHEPSKPPP AGETVTGGFG AKKRKGSSSQ APASKKLNKE ELPVIPKGKP 240
KSGRVWKDRS KKRFSQMLQD KPLRTSWQRK MKERQERKLA KDFARHLEEE KERRRQEKKQ 300
RRAENLKRRL ENERKAEVVQ VIRNPAKLKR AKKKQLRSIE KRDTLALLQK QPPQQPAAKI 360 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR026570; CCDC86. 
Pfam
  
SMART
  
PROSITE
  
PRINTS