CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042230
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Malic enzyme 
Protein Synonyms/Alias
  
Gene Name
 LOC100720540 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
156NWPENHVKAVVVTDGacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 
Functional Description
  
Sequence Annotation
 ACT_SITE 112 112 Proton donor (By similarity).
 ACT_SITE 183 183 Proton acceptor (By similarity).
 METAL 255 255 Divalent metal cation (By similarity).
 METAL 256 256 Divalent metal cation (By similarity).
 METAL 279 279 Divalent metal cation (By similarity).  
Keyword
 Complete proteome; Metal-binding; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 584 AA 
Protein Sequence
MFSRLRAAAT PCSLACRHLH TKEKGKPLML NPRTNKGMAF TLQERQMLGL QGLLPPKIET 60
QDIQALRFHK NLKKMTSPLE KYIYIMGIQE RNEKLFYRIL QDDIESLMPI VYTPTVGLAC 120
SQYGHIFRRP KGLFISISDR GHVRSIVDNW PENHVKAVVV TDGERILGLG DLGVYGMGIP 180
VGKLCLYTAC AGIRPDRCLP VCIDVGTDNQ ALLKDPFYMG LYQKRDRSQL YDDLIDEFMK 240
AITDRYGRNT LIQFEDFGNH NAFRFLRKYR EKYCTFNDDI QGTAAVALAG LLAAQKVISK 300
PISDHKILFL GAGEAALGIA NLIIMSMVEN GLSEEEAQKK IWMFDKYGLL VKGRDAKIDS 360
HQEPFVHSAP ESIPNTFEDA VNILKPSAII GVAGAGRLFT PEVIKSMARI NERPIIFALS 420
NPTAKAECTP EEAYTLTEGR CLFASGSPFG PVKLQDGRIF TPGQGNNVYI FPGVALAVIL 480
CHTRHISDNV FLEAAKALTS QLTDEELAQG RLYPPLANIQ EVSINIAIKV TEYLYTNKMA 540
FRYPEPEDKA KYVKERIWRS EYDSLLPDMY EWPEAASRPP PITE 584 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016619; F:malate dehydrogenase (oxaloacetate-decarboxylating) activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro. 
Interpro
 IPR015884; Malic_enzyme_CS.
 IPR012301; Malic_N.
 IPR012302; Malic_NAD-bd.
 IPR001891; Malic_OxRdtase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00390; malic
 PF03949; Malic_M 
SMART
 SM00919; Malic_M 
PROSITE
 PS00331; MALIC_ENZYMES 
PRINTS
 PR00072; MALOXRDTASE.