UniProt Accession

 HDAC1_DROME; Q94517; O17429; O77213; Q9VZA1 

Genbank Protein ID

 Y09258; AF086715; AF026949; AE014296; AY058487 

Genbank Nucleotide ID

 CAA70455.1; AAC61494.1; AAC23917.1; AAF47924.1; AAL13716.1 

Protein Name

 Histone deacetylase Rpd3 

Protein Synonyms/Alias

 HD; dRPD3 

Gene Name

 Rpd3 

Gene Synonyms/Alias

 HDAC1; CG7471 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
462	SETSSEIKDEKEKGD	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Catalyzes the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). 

Sequence Annotation

 REGION 7 319 Histone deacetylase.
 ACT_SITE 139 139 By similarity.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 419 419 Phosphoserine.
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 455 455 Phosphoserine.
 MOD_RES 457 457 Phosphothreonine.  

Keyword

 Chromatin regulator; Complete proteome; Developmental protein; Hydrolase; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 521 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:UniProtKB.
 GO:0035098; C:ESC/E(Z) complex; IDA:FlyBase.
 GO:0031523; C:Myb complex; IDA:FlyBase.
 GO:0016581; C:NuRD complex; IPI:FlyBase.
 GO:0005705; C:polytene chromosome interband; IDA:FlyBase.
 GO:0016580; C:Sin3 complex; NAS:FlyBase.
 GO:0004407; F:histone deacetylase activity; TAS:UniProtKB.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0003714; F:transcription corepressor activity; IPI:FlyBase.
 GO:0008134; F:transcription factor binding; TAS:UniProtKB.
 GO:0007350; P:blastoderm segmentation; IMP:FlyBase.
 GO:0006342; P:chromatin silencing; IMP:FlyBase.
 GO:0070983; P:dendrite guidance; IMP:FlyBase.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0007517; P:muscle organ development; IMP:FlyBase.
 GO:0050771; P:negative regulation of axonogenesis; IMP:FlyBase.
 GO:2001229; P:negative regulation of response to gamma radiation; IMP:FlyBase.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.
 GO:0048477; P:oogenesis; TAS:FlyBase.
 GO:0022904; P:respiratory electron transport chain; IDA:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006099; P:tricarboxylic acid cycle; IDA:FlyBase. 

Interpro

 IPR000286; His_deacetylse.
 IPR003084; His_deacetylse_1.
 IPR023801; His_deacetylse_dom. 

Pfam

 PF00850; Hist_deacetyl 

SMART

  

PROSITE

  

PRINTS

 PR01270; HDASUPER.
 PR01271; HISDACETLASE.