| Tag | Content |
|---|
| CPLM ID | CPLM-006333 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribosomal large subunit pseudouridine synthase D |
Protein Synonyms/Alias | 23S rRNA pseudouridine(1911/1915/1917) synthase; rRNA pseudouridylate synthase D; rRNA-uridine isomerase D |
Gene Name | rluD |
Gene Synonyms/Alias | sfhB; yfiI; b2594; JW2576 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 37 | DYSRSRIKEWILDQR | acetylation | [1] | | 140 | GIVHRLDKDTTGLMV | acetylation | [1] | | 206 | MAVHPMGKPAVTHYR | acetylation | [1] | | 320 | RADFEEHKDEVDWL* | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA. Isomerization occurs as a late step during the assembly of the large ribosomal subunit. |
Sequence Annotation | DOMAIN 18 91 S4 RNA-binding.
ACT_SITE 139 139 |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Isomerase; Reference proteome; RNA-binding; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 326 AA |
Protein Sequence | MAQRVQLTAT VSENQLGQRL DQALAEMFPD YSRSRIKEWI LDQRVLVNGK VCDKPKEKVL 60
GGEQVAINAE IEEEARFEPQ DIPLDIVYED EDIIIINKPR DLVVHPGAGN PDGTVLNALL 120
HYYPPIADVP RAGIVHRLDK DTTGLMVVAK TVPAQTRLVE SLQRREITRE YEAVAIGHMT 180
AGGTVDEPIS RHPTKRTHMA VHPMGKPAVT HYRIMEHFRV HTRLRLRLET GRTHQIRVHM 240
AHITHPLVGD PVYGGRPRPP KGASEAFIST LRKFDRQALH ATMLRLYHPI SGIEMEWHAP 300
IPQDMVELIE VMRADFEEHK DEVDWL 326 |
Gene Ontology | GO:0009982; F:pseudouridine synthase activity; IDA:EcoCyc. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IMP:EcoCyc. GO:0000027; P:ribosomal large subunit assembly; IMP:EcoCyc. |
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PROSITE | |
PRINTS | |