UniProt Accession

 RIC3_HUMAN; Q7Z5B4; B0B1U0; B2RD25; D3DQU5; Q6UX78; Q7Z5B3; Q86T94; Q8TBJ9; Q9HAH8 

Genbank Protein ID

 AY326435; AY326436; AM422214; AY358475; AK021670; AK315379; AL832601; AC091013; AC116456; AC129895; CH471064; CH471064; BC022455 

Genbank Nucleotide ID

 AAP92162.1; AAP92163.1; CAM12309.1; AAQ88839.1; BAB13871.1; BAG37772.1; CAD89943.1; EAW68628.1; EAW68630.1; AAH22455.1 

Protein Name

 Protein RIC-3 

Protein Synonyms/Alias

 Resistant to inhibitor of cholinesterase 3 

Gene Name

 RIC3 

Gene Synonyms/Alias

 UNQ720/PRO1385 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
202	TRVMKEGKFIDRFSP	acetylation	[1]
202	TRVMKEGKFIDRFSP	ubiquitination	[2, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
 Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D.
 Proteomics. 2007 Mar;7(6):868-74. [PMID: 17370265]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. 

Sequence Annotation

 MOD_RES 202 202 N6-acetyllysine; alternate.
 CROSSLNK 202 202 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Isopeptide bond; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043623; P:cellular protein complex assembly; IEA:Compara.
 GO:0006457; P:protein folding; IEA:Compara. 

Interpro

 IPR026160; Ric3. 

Pfam

  

SMART

  

PROSITE

  

PRINTS