CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017756
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chaperone activity of bc1 complex-like, mitochondrial 
Protein Synonyms/Alias
 Chaperone-ABC1-like; aarF domain-containing protein kinase 3 
Gene Name
 ADCK3 
Gene Synonyms/Alias
 CABC1; PP265 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246SEDPSGKKAVLGSSPubiquitination[1, 2]
295FINPHLAKIFERVRQubiquitination[1, 2]
310SADFMPLKQMMKTLNubiquitination[1, 2]
314MPLKQMMKTLNNDLGubiquitination[1, 2]
327LGPNWRDKLEYFEERubiquitination[1, 2]
642EAYSNYCKRQAQQ**ubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. 
Sequence Annotation
 DOMAIN 329 518 Protein kinase.  
Keyword
 Alternative splicing; ATP-binding; Chaperone; Complete proteome; Disease mutation; Kinase; Mitochondrion; Neurodegeneration; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 647 AA 
Protein Sequence
MAAILGDTIM VAKGLVKLTQ AAVETHLQHL GIGGELIMAA RALQSTAVEQ IGMFLGKVQG 60
QDKHEEYFAE NFGGPEGEFH FSVPHAAGAS TDFSSASAPD QSAPPSLGHA HSEGPAPAYV 120
ASGPFREAGF PGQASSPLGR ANGRLFANPR DSFSAMGFQR RFFHQDQSPV GGLTAEDIEK 180
ARQAKARPEN KQHKQTLSEH ARERKVPVTR IGRLANFGGL AVGLGFGALA EVAKKSLRSE 240
DPSGKKAVLG SSPFLSEANA ERIVRTLCKV RGAALKLGQM LSIQDDAFIN PHLAKIFERV 300
RQSADFMPLK QMMKTLNNDL GPNWRDKLEY FEERPFAAAS IGQVHLARMK GGREVAMKIQ 360
YPGVAQSINS DVNNLMAVLN MSNMLPEGLF PEHLIDVLRR ELALECDYQR EAACARKFRD 420
LLKGHPFFYV PEIVDELCSP HVLTTELVSG FPLDQAEGLS QEIRNEICYN ILVLCLRELF 480
EFHFMQTDPN WSNFFYDPQQ HKVALLDFGA TREYDRSFTD LYIQIIRAAA DRDRETVRAK 540
SIEMKFLTGY EVKVMEDAHL DAILILGEAF ASDEPFDFGT QSTTEKIHNL IPVMLRHRLV 600
PPPEETYSLH RKMGGSFLIC SKLKARFPCK AMFEEAYSNY CKRQAQQ 647 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0008219; P:cell death; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR004147; UbiB_dom. 
Pfam
 PF03109; ABC1 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM 
PRINTS