UniProt Accession

 FUCO2_HUMAN; Q9BTY2; Q7Z6Y2; Q8NBK4 

Genbank Protein ID

 AY358551; AK075458; AL031320; BC003060; BC051268 

Genbank Nucleotide ID

 AAQ88915.1; BAC11633.1; CAB53746.1; AAH03060.1; AAH51268.1 

Protein Name

 Plasma alpha-L-fucosidase 

Protein Synonyms/Alias

 Alpha-L-fucoside fucohydrolase 2; Alpha-L-fucosidase 2 

Gene Name

 FUCA2 

Gene Synonyms/Alias

 PSEC0151; UNQ227/PRO260 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
85	WQKEKIPKYVEFMKD	ubiquitination	[1, 2]
99	DNYPPSFKYEDFGPL	ubiquitination	[3]
414	QLFLGHPKAILGATE	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. 

Sequence Annotation

 CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...).
 CARBOHYD 377 377 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Glycosidase; Hydrolase; Polymorphism; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 467 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004560; F:alpha-L-fucosidase activity; IEA:EC.
 GO:0006004; P:fucose metabolic process; IEA:InterPro. 

Interpro

 IPR013780; Glyco_hydro_13_b.
 IPR000933; Glyco_hydro_29.
 IPR018526; Glyco_hydro_29_CS.
 IPR016286; Glyco_hydro_29_sub.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 

Pfam

 PF01120; Alpha_L_fucos 

SMART

 SM00812; Alpha_L_fucos 

PROSITE

 PS00385; ALPHA_L_FUCOSIDASE 

PRINTS

 PR00741; GLHYDRLASE29.