UniProt Accession

 YQJG_ECOLI; P42620; Q2M9A4 

Genbank Protein ID

 U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAA57906.1; AAC76137.1; BAE77152.1 

Protein Name

 Glutathionyl-hydroquinone reductase YqjG 

Protein Synonyms/Alias

 GS-HQR 

Gene Name

 yqjG 

Gene Synonyms/Alias

 b3102; JW3073 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
52	TGGFIAEKDRYHLYV	acetylation	[1]
139	TVPVLWDKKNHTIVS	acetylation	[1]
166	AFDALGAKAGDYYPP	acetylation	[1]
212	AYDEAVAKVFESLAR	acetylation	[1]
301	NHYFRSHKTINPTGI	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates, such as GS-p-hydroquinone (GS-HQ), GS-hydroxy-p-hydroquinone (GS-HHQ), GS- methyl-p-hydroquinone (GS-MHQ), GS-menadiol, and GS-trichloro-p- hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide- bond reduction activity toward HED (2-hydroxyethyl disulfide), and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2,4-dinitrobenzene (CDNB). 

Sequence Annotation

 DOMAIN 172 296 GST C-terminal.
 REGION 130 133 Glutathione binding.
 REGION 148 149 Glutathione binding.
 REGION 203 311 Dimerization.
 ACT_SITE 63 63 Nucleophile.
 ACT_SITE 195 195 Proton donor/acceptor (Probable).
 BINDING 96 96 Glutathione.  

Keyword

 3D-structure; Complete proteome; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 328 AA 

Protein Sequence

Gene Ontology

 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR016639; GST.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS50405; GST_CTER 

PRINTS