| Tag | Content |
|---|
| CPLM ID | CPLM-023840 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Meiosis arrest female protein 1 |
Protein Synonyms/Alias | Limkain-b1 |
Gene Name | KIAA0430 |
Gene Synonyms/Alias | LKAP; MARF1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 73 | SPLHAGSKLFPAVPL | ubiquitination | [1] | | 318 | CGTKGTGKETTLLLA | ubiquitination | [1] | | 330 | LLATSLGKAASKFGS | ubiquitination | [1] | | 585 | IIVSFTPKNRELCET | ubiquitination | [1] | | 822 | FARHGKVKSVELSPH | ubiquitination | [1] | | 1033 | DPWLLRSKSPVGNPQ | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Essential regulator of oogenesis required for female meiotic progression. Acts by down-regulating RNA transcripts, either at transcriptional of post-transcriptional level (By similarity). |
Sequence Annotation | DOMAIN 353 490 NYN.
DOMAIN 791 870 RRM.
DOMAIN 875 949 HTH OST-type 1.
DOMAIN 1003 1079 HTH OST-type 2.
DOMAIN 1099 1173 HTH OST-type 3.
DOMAIN 1175 1250 HTH OST-type 4.
DOMAIN 1259 1334 HTH OST-type 5.
DOMAIN 1335 1410 HTH OST-type 6.
DOMAIN 1411 1485 HTH OST-type 7.
DOMAIN 1486 1560 HTH OST-type 8.
MOD_RES 699 699 Phosphotyrosine (By similarity).
MOD_RES 1091 1091 Phosphoserine.
MOD_RES 1093 1093 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Differentiation; Meiosis; Oogenesis; Peroxisome; Phosphoprotein; Reference proteome; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1742 AA |
Protein Sequence | MMEGNGTENS CSRTRGWLQQ DNDAKPWLWK FSNCFSRPEQ TLPHSPQTKE YMENKKVAVE 60
LKDVPSPLHA GSKLFPAVPL PDIRSLQQPK IQLSSVPKVS CCAHCPNEPS TSPMRFGGGG 120
GGSGGTSSLI HPGALLDSQS TRTITCQVGS GFAFQSASSL QNASARNNLA GIASDFPSMC 180
LESNLSSCKH LPCCGKLHFQ SCHGNVHKLH QFPSLQGCTS AGYFPCSDFT SGAPGHLEEH 240
ISQSELTPHL CTNSLHLNVV PPVCLKGSLY CEDCLNKPAR NSIIDAAKVW PNIPPPNTQP 300
APLAVPLCNG CGTKGTGKET TLLLATSLGK AASKFGSPEV AVAGQVLENL PPIGVFWDIE 360
NCSVPSGRSA TAVVQRIREK FFKGHREAEF ICVCDISKEN KEVIQELNNC QVTVAHINAT 420
AKNAADDKLR QSLRRFANTH TAPATVVLVS TDVNFALELS DLRHRHGFHI ILVHKNQASE 480
ALLHHANELI RFEEFISDLP PRLPLKMPQC HTLLYVYNLP ANKDGKSVSN RLRRLSDNCG 540
GKVLSITGCS AILRFINQDS AERAQKRMEN EDVFGNRIIV SFTPKNRELC ETKSSNAIAD 600
KVKSPKKLKN PKLCLIKDAS EQSSSAKATP GKGSQANSGS ATKNTNVKSL QELCRMESKT 660
GHRNSEHQQG HLRLVVPTHG NSSAAVSTPK NSGVAEPVYK TSQKKENLSA RSVTSSPVEK 720
KDKEETVFQV SYPSAFSKLV ASRQVSPLLA SQSWSSRSMS PNLLNRASPL AFNIANSSSE 780
ADCPDPFANG ADVQVSNIDY RLSRKELQQL LQEAFARHGK VKSVELSPHT DYQLKAVVQM 840
ENLQDAIGAV NSLHRYKIGS KKILVSLATG AASKSLSLLS AETMSVLQDA PACCLPLFKF 900
TDIYEKKFGH KLNVSDLYKL TDTVAIREQG NGRLVCLLPS SQARQSPLGS SQSHDGSSTN 960
CSPIIFEELE YHEPVCRQHC SNKDFSEHEF DPDSYKIPFV ILSLKTFAPQ VHSLLQTHEG 1020
TVPLLDPWLL RSKSPVGNPQ LIQFSREVID LLKSQPSCVI PISHFIPSYH HHFAKQCRVS 1080
DYGYSKLIEL LEAVPHVLQI LGMGSKRLLT LTHRAQVKRF TQDLLKLLKS QASKQVIVRE 1140
FSQAYHWCFS KDWDVTEYGV CELIDIVSEI PDTTICLSQQ DNEMVICIPK RERTQDEIER 1200
TKQFSKDVVD LLRHQPHFRM PFNKFIPSYH HHFGRQCKLA YYGFTKLLEL FEAIPDTLQV 1260
LECGEEKILT LTEVERFKAL AAQFVKLLRS QKDNCLMMTD LLTEYAKTFG YTFRLQDYDV 1320
SSISALTQKL CHVVKVADIE SGRQIQLINR KSLRSLTAQL LVLLMSWEGT THLSVEELKR 1380
HYESTHNTPL NPCEYGFMTL TELLKSLPYL VEVFTNDKME ECVKLTSLYL FAKNVRSLLH 1440
TYHYQQIFLH EFSMAYTKYV GETLQPKTYG HSSVEELLGA IPQVVWIKGH GHKRIVVLKN 1500
DMKSRLSSLS LSPANHENQP SEGERILEVP ESHTASELKL GADGSGPSHT EQELLRLTDD 1560
SPVDLLCAPV PSCLPSPQLR PDPVILQSAD LIQFEERPQE PSEIMILNQE EKMEIPIPGK 1620
SKTLTSDSSS SCISAAVPVP PCPSSETSES LLSKDPVESP AKKQPKNRVK LAANFSLAPI 1680
TKL 1683 |
Gene Ontology | GO:0005777; C:peroxisome; IDA:UniProtKB. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007143; P:female meiosis; ISS:UniProtKB. GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB. GO:0048477; P:oogenesis; ISS:UniProtKB. GO:0010468; P:regulation of gene expression; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |