CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013791
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integral membrane protein 2C 
Protein Synonyms/Alias
 CT-BRI3 
Gene Name
 Itm2c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
14QPAVAGVKAEKADKAubiquitination[1]
20VKAEKADKAAASGPAubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). 
Sequence Annotation
 DOMAIN 138 232 BRICHOS.
 MOD_RES 39 39 Phosphothreonine (By similarity).
 CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Lysosome; Membrane; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 269 AA 
Protein Sequence
MVKISFQPAV AGVKAEKADK AAASGPASAS APAAEILLTP AREERPPRHR SRKGGSVGGV 60
CYLSMGMVVL LMGLVFASVY IYRYFFLAQL ARDNFFHCGV LYEDSLSSQI RTRLELEEDV 120
KIYLEENYER INVPVPQFGG GDPADIIHDF QRGLTAYHDI SLDKCYVIEL NTTIVLPPRN 180
FWELLMNVKR GTYLPQTYII QEEMVVTEHV RDKEALGSFI YHLCNGKDTY RLRRRATRRR 240
INKRGAKNCN AIRHFENTFV VETLICGVV 269 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0001540; F:beta-amyloid binding; IEA:Compara.
 GO:0012502; P:induction of programmed cell death; IEA:Compara.
 GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
 GO:0030182; P:neuron differentiation; ISS:UniProtKB. 
Interpro
 IPR007084; BRICHOS_dom. 
Pfam
 PF04089; BRICHOS 
SMART
 SM01039; BRICHOS 
PROSITE
 PS50869; BRICHOS 
PRINTS