| Tag | Content |
|---|
| CPLM ID | CPLM-022091 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sorting nexin-15 |
Protein Synonyms/Alias | |
Gene Name | SNX15 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 6 | **MSRQAKDDFLRHY | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. |
Sequence Annotation | DOMAIN 1 130 PX.
DOMAIN 265 342 MIT.
BINDING 51 51 Phosphatidylinositol 3-phosphate (By
BINDING 53 53 Phosphatidylinositol 3-phosphate; via
BINDING 87 87 Phosphatidylinositol 3-phosphate (By
BINDING 96 96 Phosphatidylinositol 3-phosphate (By
MOD_RES 227 227 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Lipid-binding; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 342 AA |
Protein Sequence | MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK RYSDFRKLHG 60
DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK 120
EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP PDDPRLSQLL PAERRGLEEL EVPVDPPPSS 180
PAQEALDLLF NCESTEEASG SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE 240
SARLDQEPWE PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH 300
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP 342 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; NAS:UniProtKB. GO:0016020; C:membrane; NAS:UniProtKB. GO:0005730; C:nucleolus; IDA:HPA. GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. GO:0008565; F:protein transporter activity; NAS:UniProtKB. GO:0007154; P:cell communication; IEA:InterPro. GO:0006886; P:intracellular protein transport; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |