UniProt Accession

 HA1L_MOUSE; P01897; Q31195; Q31196; Q31197 

Genbank Protein ID

 M33151; V00749; V00750; V00751; V00752; L00129; J00394; L00128; L00127 

Genbank Nucleotide ID

 AAA39659.1; CAA24126.1; CAA24127.1; CAA24128.1; CAA24129.1; AAA39662.1; AAA39578.1; AAA39661.1; AAA39661.1 

Protein Name

 H-2 class I histocompatibility antigen, L-D alpha chain 

Protein Synonyms/Alias

  

Gene Name

 H2-L 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	SVGYVDNKEFVRFDS	ubiquitination	[1]
170	AAQITRRKWEQAGAA	ubiquitination	[1]
340	RRRNTGGKGGDYALA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system. 

Sequence Annotation

 DOMAIN 209 297 Ig-like C1-type.
 REGION 25 114 Alpha-1.
 REGION 115 206 Alpha-2.
 REGION 207 298 Alpha-3.
 REGION 299 309 Connecting peptide.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 356 356 Phosphoserine.
 CARBOHYD 110 110 N-linked (GlcNAc...).
 CARBOHYD 200 200 N-linked (GlcNAc...).
 CARBOHYD 280 280 N-linked (GlcNAc...) (Probable).
 DISULFID 125 188
 DISULFID 227 283  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
 GO:0006952; P:defense response; TAS:MGI.
 GO:0006955; P:immune response; IEA:InterPro. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.