UniProt Accession

 PTPRB_MOUSE; B2RU80; Q3UGZ7; Q8CIW2 

Genbank Protein ID

 AY077755; AK147439; AK147668; CH466539; BC141006; BC145111 

Genbank Nucleotide ID

 AAL75813.1; BAE27912.1; BAE28060.1; EDL21786.1; AAI41007.1; AAI45112.1 

Protein Name

 Receptor-type tyrosine-protein phosphatase beta 

Protein Synonyms/Alias

 Protein-tyrosine phosphatase beta; R-PTP-beta; Vascular endothelial protein tyrosine phosphatase; VE-PTP 

Gene Name

 Ptprb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
1675	VHLNLGQKGNRKTSC	ubiquitination	[1]
1695	QFEGHFMKLQADSNY	ubiquitination	[1]
1746	PYDASRVKLCNVDDD	ubiquitination	[1]
1969	RDVLRAKKLRNEQEN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. 

Sequence Annotation

 DOMAIN 23 109 Fibronectin type-III 1.
 DOMAIN 111 202 Fibronectin type-III 2.
 DOMAIN 204 289 Fibronectin type-III 3.
 DOMAIN 290 376 Fibronectin type-III 4.
 DOMAIN 378 466 Fibronectin type-III 5.
 DOMAIN 468 553 Fibronectin type-III 6.
 DOMAIN 555 642 Fibronectin type-III 7.
 DOMAIN 644 731 Fibronectin type-III 8.
 DOMAIN 732 818 Fibronectin type-III 9.
 DOMAIN 820 907 Fibronectin type-III 10.
 DOMAIN 908 994 Fibronectin type-III 11.
 DOMAIN 996 1084 Fibronectin type-III 12.
 DOMAIN 1086 1173 Fibronectin type-III 13.
 DOMAIN 1174 1261 Fibronectin type-III 14.
 DOMAIN 1262 1354 Fibronectin type-III 15.
 DOMAIN 1356 1444 Fibronectin type-III 16.
 DOMAIN 1449 1551 Fibronectin type-III 17.
 DOMAIN 1704 1964 Tyrosine-protein phosphatase.
 REGION 1905 1911 Substrate binding (By similarity).
 ACT_SITE 1905 1905 Phosphocysteine intermediate (By
 BINDING 1871 1871 Substrate (By similarity).
 BINDING 1949 1949 Substrate (By similarity).
 CARBOHYD 28 28 N-linked (GlcNAc...) (Potential).
 CARBOHYD 53 53 N-linked (GlcNAc...) (Potential).
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 199 199 N-linked (GlcNAc...) (Potential).
 CARBOHYD 268 268 N-linked (GlcNAc...) (Potential).
 CARBOHYD 415 415 N-linked (GlcNAc...) (Potential).
 CARBOHYD 422 422 N-linked (GlcNAc...) (Potential).
 CARBOHYD 480 480 N-linked (GlcNAc...) (Potential).
 CARBOHYD 575 575 N-linked (GlcNAc...) (Potential).
 CARBOHYD 599 599 N-linked (GlcNAc...) (Potential).
 CARBOHYD 653 653 N-linked (GlcNAc...) (Potential).
 CARBOHYD 830 830 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1041 1041 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1097 1097 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1164 1164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1186 1186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1213 1213 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1275 1275 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1368 1368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1471 1471 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1475 1475 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1519 1519 N-linked (GlcNAc...) (Potential).  

Keyword

 Angiogenesis; Complete proteome; Glycoprotein; Hydrolase; Membrane; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1998 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0001525; P:angiogenesis; IDA:UniProtKB.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00041; fn3
 PF00102; Y_phosphatase 

SMART

 SM00060; FN3
 SM00194; PTPc 

PROSITE

 PS50853; FN3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS

 PR00700; PRTYPHPHTASE.