CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ras-responsive element-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 RREB1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
435PATKDSIKHLSLQPFubiquitination[1]
615LSMEAKIKQEITEGEubiquitination[2]
640KKTPAMRKVLYPCRFubiquitination[2]
763RLCGEDLKHYRALRIubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 778 AA 
Protein Sequence
MTSSSPAGLE GSDLSSINTM MSAVMSVGKV TENGGSPQGI KSPSKPPGPN RIGRRNQETK 60
EEKSSYNCPL CEKICTTQHQ LTMHIRQHNT DTGGADHSCS ICGKSLSSAS SLDRHMLVHS 120
GERPYKCTVC GQSFTTNGNM HRHMKIHEKD PNSATATAPP SPLKRRRLSS KRKLSHDAES 180
EREDPAPAKK MVEDGQSGDL EKKADEVFHC PVCFKEFVCK YGLETHMETH SDNPLRCDIC 240
CVTFRTHRGL LRHNALVHKQ LPRDAMGRPF IQNNPSIPAG FHDLGFTDFS CRKFPRISQA 300
WCETNLRRCI SEQHRFVCDT CDKAFPMLCS LALHKQTHVA ADQGQEKPQA TPLPGDALDQ 360
KGFLALLGLQ HTKDVRPAPA EEPLPDDNQA IQLQTLKCQL PQDPGCTNLL SLSPFEAASL 420
GGSLTVLPAT KDSIKHLSLQ PFQKGFIIQP DSSIVVKPIS GESAIELADI QQILKMAASA 480
PPQISLPPFS KAPAAPLQAI FKHMPPLKPK PLVTPRTVVA TSTPPPLINA QQASPGCISP 540
SLPPPPLKLL KGSVEAASNA HLLQSKSGTQ PHAATRLSLQ QPRAELPGQP EMKTQLEQDS 600
IIEALLPLSM EAKIKQEITE GELKAFMTAP GGKKTPAMRK VLYPCRFCNQ VFAFSGVLRA 660
HVRSHLGISP YQCNICDYIA ADKAALIRHL RTHSGERPYI CKICHYPFTV KANCERHLRK 720
KHLKATRKDI EKNIEYVSSS AAELVDAFCA PDTVCRLCGE DLKHYRALRI HMRTHCGR 778 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS