CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013655
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinate-nucleotide pyrophosphorylase [carboxylating] 
Protein Synonyms/Alias
 Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase 
Gene Name
 Qprt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
86SKLVPVVKVAEVRGPacetylation[1]
171LGGLVMVKDNHVVAAacetylation[1]
183VAAGSMEKAVLKARQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in the catabolism of quinolinic acid (QA) (By similarity). 
Sequence Annotation
 REGION 137 139 Substrate binding (By similarity).
 REGION 248 250 Substrate binding (By similarity).
 REGION 269 271 Substrate binding (By similarity).
 BINDING 102 102 Substrate (By similarity).
 BINDING 161 161 Substrate (By similarity).
 BINDING 171 171 Substrate (By similarity).
 BINDING 201 201 Substrate (By similarity).
 BINDING 222 222 Substrate (By similarity).  
Keyword
 Complete proteome; Glycosyltransferase; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MDPEGLQFLL PPASLAALAN SWLQEDCPGL NFASLVTGSA PAQAVLWAKS PGVLAGRPFF 60
DAIFTQLNCQ VSWLLPEGSK LVPVVKVAEV RGPAHHLLLG ERVALNTLAR CSGIASAAAT 120
AVEVATSTGW AGHVAGTRKT TPGFRLVEKY GLLVGGAECH RYDLGGLVMV KDNHVVAAGS 180
MEKAVLKARQ AAGFPLKVEV ECSSLKEALQ AAEAGADLVM LDNFKPEELH PTAATLKAKF 240
PNVSVEASGG VTLDNLPQFC GTNIDVISLG MLTQAAPALD FSLKLYAEGD IPVPHARRS 299 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IDA:RGD.
 GO:0009435; P:NAD biosynthetic process; IDA:RGD.
 GO:0051259; P:protein oligomerization; IEA:Compara.
 GO:0034213; P:quinolinate catabolic process; IEA:Compara.
 GO:0046874; P:quinolinate metabolic process; IDA:RGD. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR004393; NadC.
 IPR027277; NadC/ModD.
 IPR002638; Quinolinate_PRibosylTrfase_C.
 IPR022412; Quinolinate_PRibosylTrfase_N. 
Pfam
 PF01729; QRPTase_C
 PF02749; QRPTase_N 
SMART
  
PROSITE
  
PRINTS