UniProt Accession

 INS_PIG; P01315; Q9TSJ5 

Genbank Protein ID

 AF064555; AY044828; AY242098; AY242099; AY242100; AY242101; AY242102; AY242103; AY242104; AY242105; AY242106; AY242107; AY242108; AY242109; AY242110; AY242111; AY242112 

Genbank Nucleotide ID

 AAC77920.1; AAL69550.1; AAQ00952.1; AAQ00954.1; AAQ00957.1; AAQ00960.1; AAQ00963.1; AAQ00966.1; AAQ00969.1; AAQ00972.1; AAQ00975.1; AAQ00978.1; AAQ00981.1; AAQ00983.1; AAQ00985.1; AAQ00987.1; AAQ00990.1 

Protein Name

 Insulin 

Protein Synonyms/Alias

 Insulin B chain; Insulin A chain 

Gene Name

 INS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Sus scrofa (Pig) 

NCBI Taxa ID

 9823 

Lysine Modification

Position	Peptide	Type	References
53	RGFFYTPKARREAEN	acetylation	[1]

Reference

 [1] The acetylation of insulin.
 Lindsay DG, Shall S.
 Biochem J. 1971 Mar;121(5):737-45. [PMID: 5113488] 

Functional Description

 Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. 

Sequence Annotation

 DISULFID 31 94 Interchain (between B and A chains).
 DISULFID 43 107 Interchain (between B and A chains).
 DISULFID 93 98  

Keyword

 3D-structure; Carbohydrate metabolism; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glucose metabolism; Hormone; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
 GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL.
 GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
 GO:0046628; P:positive regulation of insulin receptor signaling pathway; IDA:BHF-UCL.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL.
 GO:0031954; P:positive regulation of protein autophosphorylation; IDA:BHF-UCL. 

Interpro

 IPR004825; Insulin.
 IPR016179; Insulin-like.
 IPR022353; Insulin_CS.
 IPR022352; Insulin_family. 

Pfam

 PF00049; Insulin 

SMART

 SM00078; IlGF 

PROSITE

 PS00262; INSULIN 

PRINTS

 PR00277; INSULIN.
 PR00276; INSULINFAMLY.