UniProt Accession

 SGT2_YEAST; Q12118; D6W273 

Genbank Protein ID

 U43491; Z74915; BK006948 

Genbank Nucleotide ID

 AAC49487.1; CAA99195.1; DAA10789.1 

Protein Name

 Small glutamine-rich tetratricopeptide repeat-containing protein 2 

Protein Synonyms/Alias

 SGT/UBP; Viral protein U-binding protein 

Gene Name

 SGT2 

Gene Synonyms/Alias

 YOR007C; UNF346 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
57	AVSGILGKSEFKGQH	acetylation	[1]
61	ILGKSEFKGQHLADI	acetylation	[1]
106	KAKAEDLKMQGNKAM	acetylation	[1]
116	GNKAMANKDYELAIN	acetylation	[1]
116	GNKAMANKDYELAIN	ubiquitination	[2]
124	DYELAINKYTEAIKV	acetylation	[1]
130	NKYTEAIKVLPTNAI	acetylation	[1]
150	AAAHSSLKEYDQAVK	acetylation	[1]
194	EEALEAYKKVLDIEG	acetylation	[1]
195	EALEAYKKVLDIEGD	ubiquitination	[2]
209	DNATEAMKRDYESAK	acetylation	[1]
209	DNATEAMKRDYESAK	ubiquitination	[2]
218	DYESAKKKVEQSLNL	ubiquitination	[2]
227	EQSLNLEKTVPEQSR	ubiquitination	[2]
288	GAMQNIQKMMQDPSI	ubiquitination	[2]
345	ETPDNENKQ******	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock. 

Sequence Annotation

 REPEAT 102 135 TPR 1.
 REPEAT 136 169 TPR 2.
 REPEAT 170 203 TPR 3.
 REPEAT 205 229 TPR 4.
 MOD_RES 308 308 Phosphothreonine.  

Keyword

 3D-structure; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0072380; C:TRC complex; IDA:SGD.
 GO:0032947; F:protein complex scaffold; IMP:SGD.
 GO:0006620; P:posttranslational protein targeting to membrane; IDA:SGD.
 GO:0009408; P:response to heat; IMP:SGD. 

Interpro

 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1
 PF07719; TPR_2 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS