UniProt Accession

 THIK_HUMAN; P09110; G5E935; Q96CA6 

Genbank Protein ID

 X12966; X14813; X65140; X65148; AP006309; CH471055; BC000635; BC011977; BC014474 

Genbank Nucleotide ID

 CAA31412.1; CAA32918.1; CAA46270.1; CAA46271.1; EAW64516.1; AAH00635.1; AAH11977.1; AAH14474.1 

Protein Name

 3-ketoacyl-CoA thiolase, peroxisomal 

Protein Synonyms/Alias

 Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase 

Gene Name

 ACAA1 

Gene Synonyms/Alias

 ACAA; PTHIO 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
209	FALASQQKAARAQSK	ubiquitination	[1]
292	ILLARRSKAEELGLP	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

 ACT_SITE 123 123 Acyl-thioester intermediate (By
 ACT_SITE 377 377 Proton acceptor (By similarity).
 ACT_SITE 408 408 Proton acceptor (By similarity).
 MOD_RES 59 59 Phosphothreonine.
 MOD_RES 60 60 Phosphothreonine.  

Keyword

 3D-structure; Acyltransferase; Alternative splicing; Complete proteome; Fatty acid metabolism; Lipid metabolism; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0005782; C:peroxisomal matrix; TAS:Reactome.
 GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:EC.
 GO:0016401; F:palmitoyl-CoA oxidase activity; IMP:UniProtKB.
 GO:0036109; P:alpha-linolenic acid metabolic process; TAS:Reactome.
 GO:0008206; P:bile acid metabolic process; IMP:UniProtKB.
 GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; TAS:Reactome.
 GO:0000038; P:very long-chain fatty acid metabolic process; IMP:UniProtKB. 

Interpro

 IPR002155; Thiolase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020615; Thiolase_acyl_enz_int_AS.
 IPR020610; Thiolase_AS.
 IPR020617; Thiolase_C.
 IPR020613; Thiolase_CS.
 IPR020616; Thiolase_N. 

Pfam

 PF02803; Thiolase_C
 PF00108; Thiolase_N 

SMART

  

PROSITE

 PS00098; THIOLASE_1
 PS00737; THIOLASE_2
 PS00099; THIOLASE_3 

PRINTS