UniProt Accession

 FABZ_ECOLI; P0A6Q6; P21774 

Genbank Protein ID

 M19334; U00096; AP009048; U70214 

Genbank Nucleotide ID

 AAC36917.1; AAC73291.1; BAA77855.1; AAB08609.1 

Protein Name

 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ 

Protein Synonyms/Alias

 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl-ACP dehydrase; 17 kDa actomyosin component; Beta-hydroxyacyl-ACP dehydratase 

Gene Name

 fabZ 

Gene Synonyms/Alias

 sefA; yaeA; b0180; JW0175 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
84	LAFKSVGKLEPGELY	acetylation	[1]
119	IMEVTFEKTRRGLTR	acetylation	[1]
128	RRGLTRFKGVALVDG	acetylation	[1]
136	GVALVDGKVVCEATM	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. 

Sequence Annotation

 ACT_SITE 54 54 By similarity.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Lyase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IMP:EcoCyc.
 GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:EC.
 GO:0006633; P:fatty acid biosynthetic process; IDA:EcoCyc.
 GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP. 

Interpro

 IPR013114; FabA_FabZ.
 IPR010084; FabZ. 

Pfam

 PF07977; FabA 

SMART

  

PROSITE

  

PRINTS