CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020006
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosome-binding protein 1 
Protein Synonyms/Alias
 Ribosome receptor protein; RRp; mRRp 
Gene Name
 Rrbp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
97PNVTIILKEPVRVSAubiquitination[1]
131VPAMPQEKLASSPKDubiquitination[1]
148KKEKKVAKVEPAVSSubiquitination[1]
166SIQVLASKSAILEATubiquitination[1]
175AILEATPKEVPMVAVubiquitination[1]
188AVPPVGSKASSPATSubiquitination[1]
229EGAQNQAKKGEGAQNubiquitination[1]
349EGGQNQAKKGEGAQNubiquitination[1]
671EGPQNQAKKGEGAQNubiquitination[1]
752TVANQGTKQEGVSNQubiquitination[1]
812MAPAQGQKASMVQSQubiquitination[1]
823VQSQEAPKQDAPAKKubiquitination[1]
837KKSGSRKKGEPGPPDubiquitination[1]
880LIEILSEKTGVIQDTubiquitination[1]
894TWHKATQKGDPVAILubiquitination[1]
902GDPVAILKRQLQEKEubiquitination[1]
910RQLQEKEKLLATEQEubiquitination[1]
923QEDAAVAKSKLRELNubiquitination[1]
974ASYRDHVKEVQQLQGubiquitination[1]
982EVQQLQGKIRTLQEQubiquitination[1]
1022ATSQVESKQNTELAKubiquitination[1]
1029KQNTELAKLRQELSKubiquitination[1]
1061QRKALEAKAATFEKQubiquitination[1]
1124RVAELHSKLQSSEVEubiquitination[1]
1147SSLHGQLKEARAENSubiquitination[1]
1226DLREKNWKAMEALALubiquitination[1]
1241AERACEEKLRSLTQAacetylation[2]
1299KGSELLKKPPTLEPSubiquitination[1]
1342AETEGMLKDLQKSVEubiquitination[1]
1346GMLKDLQKSVEEEERubiquitination[1]
1358EERVWKAKVGAAEEEubiquitination[1]
1368AAEEELHKSRVTVKHubiquitination[1]
1374HKSRVTVKHLEDIVEubiquitination[1]
1382HLEDIVEKLKGELESubiquitination[1]
1384EDIVEKLKGELESSDubiquitination[1]
1440QSQLDEAKSEAQKQSubiquitination[1]
1445EAKSEAQKQSDELALubiquitination[1]
1486EQDPMKLKTQLERTEubiquitination[1]
1505AEQTRRQKLTAEFEEubiquitination[1]
1538GPLESSGKEEITQLKacetylation[2]
1564DLGRAAIKLQELLKTubiquitination[1]
1570IKLQELLKTTQEQLTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane (By similarity). 
Sequence Annotation
 REPEAT 196 205 1.
 REPEAT 206 215 2.
 REPEAT 216 225 3.
 REPEAT 226 235 4.
 REPEAT 236 245 5.
 REPEAT 246 255 6.
 REPEAT 256 265 7.
 REPEAT 266 275 8.
 REPEAT 276 285 9.
 REPEAT 286 295 10.
 REPEAT 296 305 11.
 REPEAT 306 315 12.
 REPEAT 316 325 13.
 REPEAT 326 335 14.
 REPEAT 336 345 15.
 REPEAT 346 355 16.
 REPEAT 356 365 17.
 REPEAT 366 375 18.
 REPEAT 376 385 19.
 REPEAT 386 395 20.
 REPEAT 396 405 21.
 REPEAT 406 415 22.
 REPEAT 416 425 23.
 REPEAT 426 435 24.
 REPEAT 436 445 25.
 REPEAT 446 455 26.
 REPEAT 456 465 27.
 REPEAT 466 475 28.
 REPEAT 476 485 29.
 REPEAT 486 495 30.
 REPEAT 496 505 31.
 REPEAT 506 515 32.
 REPEAT 516 525 33.
 REPEAT 527 536 34.
 REPEAT 537 546 35.
 REPEAT 547 556 36.
 REPEAT 557 566 37.
 REPEAT 567 576 38.
 REPEAT 577 586 39.
 REPEAT 587 596 40.
 REPEAT 597 606 41.
 REPEAT 607 616 42.
 REPEAT 617 626 43.
 REPEAT 628 637 44.
 REPEAT 638 647 45.
 REPEAT 648 657 46.
 REPEAT 658 667 47.
 REPEAT 668 677 48.
 REPEAT 678 687 49.
 REPEAT 688 697 50.
 REPEAT 698 707 51.
 REPEAT 708 717 52.
 REPEAT 718 727 53.
 REPEAT 729 738 54.
 REPEAT 739 748 55.
 REPEAT 749 758 56.
 REPEAT 759 768 57.
 REPEAT 769 778 58.
 REPEAT 779 788 59.
 REPEAT 789 798 60.
 REPEAT 799 808 61.
 REGION 196 808 61 X 10 AA tandem repeats of [NSQ]-
 MOD_RES 786 786 Phosphoserine (By similarity).
 MOD_RES 818 818 Phosphoserine (By similarity).
 MOD_RES 1178 1178 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Translocation; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1605 AA 
Protein Sequence
MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA KTHHQKGEKK 60
KKEKTVEKKG KTKKKEEKPN GKIPEHDLDP NVTIILKEPV RVSAVAVAPT SVHSSVGHTP 120
IATVPAMPQE KLASSPKDRK KKEKKVAKVE PAVSSIVNSI QVLASKSAIL EATPKEVPMV 180
AVPPVGSKAS SPATSSQGKK GQGAQNQAKK GEGAQNQGKK GEGAQNQAKK GEGAQNQAKK 240
GEGAQNQGKK GEGAQNQAKK GEGGQNQAKK GEGAQNQGKK GEGAQNQGKK GEGAQNQAKK 300
GEGAQNQAKK GEGAQNQGKK GEGAQNQSKK GEGAQNQAKK GEGGQNQAKK GEGAQNQAKK 360
GEGAQNQAKK GEGVQNQAKK GVEGAQNQGK KGEANQNQAK KGEGGQNQTK KGEGPQNQGK 420
KGEAAQKQDK KIEGAQNQGK KPEGTSNQGK KGEGAQNQGK KGEGAQNQSK KGEGAQNQAK 480
KGEGGQNQAK KGEGAQNQAK KGEGAQNQAK KGEGVQNQAK KGVEGAQNQG KKGEANQNQA 540
KKGEGGQNQT KKGEGPQNQG KKGEAAQKQD KKIEGAQNQG KKPEGTSNQG KKGEGAQNQG 600
KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG 660
KKGEGPQNQA KKGEGAQNQG KKGEGAQNQG KKGEGAQNQG KKAEGVQSQS KKGEGTQNQG 720
KKGDGNPNQG KKGEGASNQN RKTDTVANQG TKQEGVSNQV KKSEGSPNQG KKAEGAPNQG 780
KKKDGSPSQA KKVDAAANQG KKSEMAPAQG QKASMVQSQE APKQDAPAKK KSGSRKKGEP 840
GPPDCDGPLF LPYKTLVSTV GSMVFSEGEA QRLIEILSEK TGVIQDTWHK ATQKGDPVAI 900
LKRQLQEKEK LLATEQEDAA VAKSKLRELN KEMASEKAKA AAGEAKVKKQ LVAREQEIAA 960
VQARMQASYR DHVKEVQQLQ GKIRTLQEQL ENGPNTQLAR LQQENSILRD ALNQATSQVE 1020
SKQNTELAKL RQELSKVNKE LVEKSEASRQ EEQQRKALEA KAATFEKQVL QLQASHKESE 1080
EALQKRLEEV TRELCRAQTS HANLRADAEK AQEQQQRVAE LHSKLQSSEV EVKSKCEELS 1140
SLHGQLKEAR AENSQLTERI RSIEALLEAG QAQDTQASHA EANQQQTRLK ELESQVSCLE 1200
KETSELKEAM EQQKGKNNDL REKNWKAMEA LALAERACEE KLRSLTQAKE ESEKQLHLAE 1260
AQTKETLLAL LPGLSISAHQ NYAEWLQEFK EKGSELLKKP PTLEPSMDIV LKLREAEETQ 1320
NSLQAECDQY RTILAETEGM LKDLQKSVEE EERVWKAKVG AAEEELHKSR VTVKHLEDIV 1380
EKLKGELESS DQVREHTSHL EAELEKHMAA ASAECQNYAK EVAGLRQLLL ESQSQLDEAK 1440
SEAQKQSDEL ALVRQQLSDM RSHVEDGDVA GSPAVPPAEQ DPMKLKTQLE RTEATLEAEQ 1500
TRRQKLTAEF EEAQRTACRI QEELEKLRAA GPLESSGKEE ITQLKERLEK EKRLTSDLGR 1560
AAIKLQELLK TTQEQLTKEK DTVKKLQEQL GKAEDGSSSK EGTSV 1605 
Gene Ontology
 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; ISS:UniProtKB. 
Interpro
 IPR007794; Rib_rcpt_KP. 
Pfam
 PF05104; Rib_recp_KP_reg 
SMART
  
PROSITE
  
PRINTS