CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014758
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Junctional adhesion molecule C 
Protein Synonyms/Alias
 JAM-C; Junctional adhesion molecule 3; JAM-3 
Gene Name
 Jam3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
287ESYKSPGKHEGVNYIubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 May participate in cell-cell adhesion distinct from tight junctions (By similarity). 
Sequence Annotation
 DOMAIN 35 127 Ig-like V-type.
 DOMAIN 139 236 Ig-like C2-type.
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
 DISULFID 53 115 By similarity.
 DISULFID 160 219 By similarity.  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 310 AA 
Protein Sequence
MALSRRLRLR LCARLPDFFL LLLFRGCVIE AVNLKSSNRN PVVHEFESVE LSCIITDSQT 60
NDPRIEWKKI QDGQTTYVYF DNKIQGDLAG RTDVFGKTSL RIWNVTRSDS AIYRCEVVAL 120
NDRKEVDELT IELIVQVKPV APVCRVPKAV PVGKAATLQC QESEGYPRPY YSWYRNDVPL 180
PTDSRANPRF QNSSFHVNSE TGTLVFSAVH KEDSGQYYCI ASNDAGAARC EGQDMEVYDL 240
NIAGIIGGVL VVLIVLAVIT MGICCAYRRG CFISSKQDGE SYKSPGKHEG VNYIRTSEEG 300
DFRHKSSFVI 310 
Gene Ontology
 GO:0044291; C:cell-cell contact zone; IEA:Compara.
 GO:0030057; C:desmosome; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033010; C:paranodal junction; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0005923; C:tight junction; IEA:Compara.
 GO:0002250; P:adaptive immune response; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara.
 GO:0030010; P:establishment of cell polarity; IEA:Compara.
 GO:0002523; P:leukocyte migration involved in inflammatory response; IEA:Compara.
 GO:0042552; P:myelination; IEA:Compara.
 GO:0002318; P:myeloid progenitor cell differentiation; IEA:Compara.
 GO:0001780; P:neutrophil homeostasis; IEA:Compara.
 GO:0090138; P:regulation of actin cytoskeleton organization by cell-cell adhesion; IEA:Compara.
 GO:0090022; P:regulation of neutrophil chemotaxis; IEA:Compara.
 GO:0007286; P:spermatid development; IEA:Compara. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set. 
Pfam
 PF07686; V-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS