CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002887
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate lyase 
Protein Synonyms/Alias
 ICL; Isocitrase; Isocitratase 
Gene Name
 icl 
Gene Synonyms/Alias
 Rv0467; MT0483; MTV038.11 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
334ATIAKFQKELAAMGFpupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 
Functional Description
 Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway (By similarity). 
Sequence Annotation
 ACT_SITE 191 191
 CROSSLNK 334 334 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Glyoxylate bypass; Isopeptide bond; Lyase; Reference proteome; Tricarboxylic acid cycle; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 428 AA 
Protein Sequence
MSVVGTPKSA EQIQQEWDTN PRWKDVTRTY SAEDVVALQG SVVEEHTLAR RGAEVLWEQL 60
HDLEWVNALG ALTGNMAVQQ VRAGLKAIYL SGWQVAGDAN LSGHTYPDQS LYPANSVPQV 120
VRRINNALQR ADQIAKIEGD TSVENWLAPI VADGEAGFGG ALNVYELQKA LIAAGVAGSH 180
WEDQLASEKK CGHLGGKVLI PTQQHIRTLT SARLAADVAD VPTVVIARTD AEAATLITSD 240
VDERDQPFIT GERTREGFYR TKNGIEPCIA RAKAYAPFAD LIWMETGTPD LEAARQFSEA 300
VKAEYPDQML AYNCSPSFNW KKHLDDATIA KFQKELAAMG FKFQFITLAG FHALNYSMFD 360
LAYGYAQNQM SAYVELQERE FAAEERGYTA TKHQREVGAG YFDRIATTVD PNSSTTALTG 420
STEEGQFH 428 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MTBBASE.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0004451; F:isocitrate lyase activity; IDA:MTBBASE.
 GO:0046421; F:methylisocitrate lyase activity; IDA:MTBBASE.
 GO:0071456; P:cellular response to hypoxia; IEP:MTBBASE.
 GO:0006097; P:glyoxylate cycle; IDA:MTBBASE.
 GO:0006102; P:isocitrate metabolic process; IDA:MTBBASE.
 GO:0075141; P:maintenance of symbiont tolerance to host environment; IMP:MTBBASE.
 GO:0009405; P:pathogenesis; IDA:MTBBASE.
 GO:0010034; P:response to acetate; IDA:MTBBASE.
 GO:0001101; P:response to acid; IEP:MTBBASE.
 GO:0070542; P:response to fatty acid; IDA:MTBBASE.
 GO:0052572; P:response to host immune response; IEP:MTBBASE.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR006254; Isocitrate_lyase.
 IPR000918; Isocitrate_lyase/Pmutase.
 IPR018523; Isocitrate_lyase_ph_CS.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom. 
Pfam
 PF00463; ICL 
SMART
  
PROSITE
 PS00161; ISOCITRATE_LYASE 
PRINTS