CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018204
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Angiomotin 
Protein Synonyms/Alias
  
Gene Name
 Amot 
Gene Synonyms/Alias
 Kiaa1071 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
114LPTYEEAKVQSQYFRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity). 
Sequence Annotation
 MOTIF 1123 1126 PDZ-binding (By similarity).
 MOD_RES 691 691 Phosphoserine.  
Keyword
 Alternative splicing; Cell junction; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome; Tight junction; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1126 AA 
Protein Sequence
MRSSDDQPSG GTTVLQRLLQ EQLRYGNPSE NRSLLAIHQQ ATGNSSPFST GSGNQGPQND 60
VLSSQDHHQQ QLVAHPARQE PQGQEIQSEN GVMEKQLSPR MQNNEELPTY EEAKVQSQYF 120
RGQQHASVGA AFYVTGVTNQ KMRTEGRPSV QRLTPGKMHQ DEGLRDLKQG HVRSLSERLM 180
QMSLATSGVK AHPPVTSAPL SPPQPNDLYK NATSSSEFYK AQGPPPSQHS LKGMEHRGPP 240
PEYPFKGVPS QSVVCKSQEP GHFYSEHRLN QPGRTEGQLM RYQHPPEYGA ARATQDISSL 300
SLSARNSQPH SPTSSLTAGA SSLPLLQSPP STRLPPGQHL VSNQGDHSAH LSRHQQHLLS 360
SQSHQGDHYR HAQASLTSAQ QQPGEAYSAM PRAQQSASYQ PMPADPFAMV SRAQQMVEIL 420
SDENRNLRQE LDGCYEKVAR LQKVETEIQR VSEAYENLVK SSSKREALEK AMRNKLEGEI 480
RRMHDFNRDL RDRLETANKQ LAEKEYEGSE DTRKTISQLF AKHKENQREK EKLEAELATA 540
RSTNEDQRRH IEIRDQALSN AQAKVVKLEE ELKKKQVYVD KVEKMQQALV QLQAACEKRE 600
QLEHRLRTRL ERELESLRIQ QRQGNSQPTN ASEYNAAALM ELLREKEERI LALEADMTKW 660
EQKYLEENVM RHFALDAAAT VAAQRDTTVI SHSPNTSYDT ALEARIQKEE EEILMANKRC 720
LDMEGRIKTL HAQIIEKDAM IKVLQQRSRK EPSKTEQLSS MRPAKSLMSI SNAGSGLLAH 780
SSTLTGAPIM EEKRDDKSWK GSLGVLLGGD YRVEPVPSTP SPVPPSTPLL SAHSKTGSRD 840
CSTQTERGPE STKTAAVTPI SAPMAGPVAA AAPAAAINAT AATNTATAAT NTTIMVAAAP 900
VAVAAVAAPA AAAATPSPAN AAALAAAAAP ATSVSAATSV SAANSISPAA PVAPAAVVPP 960
AAPVSPAAAV QIPAAASLTP ATVSPTAATA TAAVAAATTA AITAAAAAAT TAIQVAPATS 1020
APVPSPASIP APATAQASAP TPTQASTPAP TEPPSPVPTP TPALVQTEGP ANPGASSGPR 1080
RLSTPNLMCN PDKPDAPAFH SSTLERKTPI QILGQEPDAE MVEYLI 1126 
Gene Ontology
 GO:0005884; C:actin filament; ISS:UniProtKB.
 GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:Compara.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0043532; F:angiostatin binding; ISS:UniProtKB.
 GO:0004872; F:receptor activity; IEA:Compara.
 GO:0030036; P:actin cytoskeleton organization; IMP:MGI.
 GO:0043534; P:blood vessel endothelial cell migration; IMP:MGI.
 GO:0042074; P:cell migration involved in gastrulation; IMP:MGI.
 GO:0034613; P:cellular protein localization; IMP:MGI.
 GO:0006935; P:chemotaxis; IMP:MGI.
 GO:0003365; P:establishment of cell polarity involved in ameboidal cell migration; IMP:MGI.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.
 GO:0035329; P:hippo signaling cascade; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0016525; P:negative regulation of angiogenesis; IEA:Compara.
 GO:0034260; P:negative regulation of GTPase activity; IMP:MGI.
 GO:0043116; P:negative regulation of vascular permeability; IEA:Compara.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Compara.
 GO:0040019; P:positive regulation of embryonic development; IMP:MGI.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IMP:MGI.
 GO:0001570; P:vasculogenesis; IMP:MGI. 
Interpro
 IPR009114; Angiomotin.
 IPR024646; Angiomotin_C. 
Pfam
 PF12240; Angiomotin_C 
SMART
  
PROSITE
  
PRINTS
 PR01807; ANGIOMOTIN.