UniProt Accession

 H17B6_MOUSE; Q9R092 

Genbank Protein ID

 AF103797; AK008212; BC021836 

Genbank Nucleotide ID

 AAF04761.1; BAB25536.1; AAH21836.1 

Protein Name

 17-beta-hydroxysteroid dehydrogenase type 6 

Protein Synonyms/Alias

 17-beta-HSD 6; 17-beta-HSD6; 17-beta-HSD9; 3-alpha->beta-hydroxysteroid epimerase; 3-alpha->beta-HSE; Oxidative 3-alpha hydroxysteroid dehydrogenase 

Gene Name

 Hsd17b6 

Gene Synonyms/Alias

 Gm182; Hsd17b9; Rdh8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
64	LAACLTEKGAEELRN	acetylation	[1]
64	LAACLTEKGAEELRN	ubiquitination	[2]
225	LTIERTKKVWEAAPE	ubiquitination	[2]
251	DDFCSTTKRELMKCS	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). 

Sequence Annotation

 NP_BIND 33 57 NAD (By similarity).
 ACT_SITE 176 176 Proton acceptor (By similarity).
 BINDING 164 164 Substrate (Potential).
 CARBOHYD 71 71 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Endoplasmic reticulum; Endosome; Glycoprotein; Lipid metabolism; Membrane; Microsome; NAD; Oxidoreductase; Reference proteome; Signal; Steroid metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:EC.
 GO:0004745; F:retinol dehydrogenase activity; IEA:EC.
 GO:0047035; F:testosterone dehydrogenase (NAD+) activity; IEA:EC.
 GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.